ArticleJournal of clinical and translational science2022
Key lessons and strategies for implementing single IRB review in the Trial Innovation Network.
Article in Journal of clinical and translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 7 citations in OpenAlex.
- Blind spots: The hidden challenges of conducting multisite intervention research.Contemporary clinical trials communications · 2026Article
- Evaluation of the National Dental PBRN central IRB since its inception in 2014 until 2025.Journal of clinical and translational science · 2026Article
- Ten years of Central IRB review for an NIH-funded large clinical trial network by an academic IRB: The NIH StrokeNet experience.Journal of clinical and translational science · 2026Article
- Accelerating start-up cycles in investigator-initiated multicenter clinical trials.Journal of clinical and translational science · 2025Article
- Insights from the trial innovation network's initial consultation process.Journal of clinical and translational science · 2025Article
- Local context review by single institutional review boards: Results from a modified Delphi process.Journal of clinical and translational science · 2025Article
- Ethical research when abortion access is legally restricted.Science (New York, N.Y.) · 2023Article
- Implementation of single IRB review for multisite human subjects research: Persistent challenges and possible solutions.Journal of clinical and translational science · 2023Article
- Development, implementation, and dissemination of operational innovations across the trial innovation network.Journal of clinical and translational science · 2023Article
- Decentralized clinical trials in the trial innovation network: Value, strategies, and lessons learned.Journal of clinical and translational science · 2023Article
- Using single IRB consultations to meet the educational needs of investigative teams.Contemporary clinical trials communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
The Trial Innovation Network has established an infrastructure for single IRB review in response to federal policies. The Network's single IRB (sIRBs) have successfully supported over 70 multisite studies via more than 800 reliance arrangements. This has generated several lessons learned that can benefit the national clinical research enterprise, as we work to improve the conduct of clinical trials. These lessons include distinguishing the roles of the single IRB from institutional Human Research Protections programs, establishing a consistent sIRB review model, standardizing collection of local context and supplemental, study-specific information, and educating and empowering lead study teams to support their sites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.