Evidence map›Paper›PMID 35656304›Full record

ArticleFrontiers in pharmacology2022

Hepatic Organoid-Based High-Content Imaging Boosts Evaluation of Stereoisomerism-Dependent Hepatotoxicity of Stilbenes in Herbal Medicines.

Juan Liu, Tingting Li, Ruihong Li, Jie Wang, Pengyan Li, Ming Niu, Le Zhang, Chunyu Li, Tao Wang, Xiaohe Xiao and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Juan LiuHepato-Pancreato-Biliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
Tingting LiIntegrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
Ruihong LiStem Cells and Tissue Engineering Lab, Institute of Health Service and Transfusion Medicine, Beijing, China.
Jie WangStem Cells and Tissue Engineering Lab, Institute of Health Service and Transfusion Medicine, Beijing, China.
Pengyan LiIntegrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
Ming NiuIntegrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
Le ZhangIntegrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
Chunyu LiIntegrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
Tao WangNephrology Combined with Traditional Chinese and Western Medicine, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Xiaohe XiaoIntegrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
Jia-Bo WangIntegrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
Yunfang WangHepato-Pancreato-Biliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
Capital Medical University · CNChinese PLA General Hospital · CNBeijing Tsinghua Chang Gung Hospital · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complexity of chemical components of herbal medicines often causes great barriers to toxicity research. In our previous study, we have found the critical divergent hepatotoxic potential of a pair of stilbene isomers in a famous traditional Chinese herb,

Indexed as

hepatotoxicityhigh-content imagingorganoidsPolygonum multiflorumstereoisomer

Identifiers

PMID35656304
PMCPMC9152290
OpenAlexW4280507484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.