Evidence map›Paper›PMID 35656291›Full record

ArticleFrontiers in pharmacology2022

Red Blood Cell Membrane-Camouflaged PLGA Nanoparticles Loaded With Basic Fibroblast Growth Factor for Attenuating Sepsis-Induced Cardiac Injury.

Xinze Li, Guangliang Hong, Guangju Zhao, Hui Pei, Jie Qu, Changju Chun, Zhiwei Huang, Zhongqiu Lu

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Xinze LiDepartment of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Guangliang HongDepartment of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Guangju ZhaoDepartment of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Hui PeiDepartment of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jie QuDepartment of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Changju ChunResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University, Gwangju, South Korea.
Zhiwei HuangResearch Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University, Gwangju, South Korea.
Zhongqiu LuDepartment of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Wenzhou Medical University · CNChonnam National University · KRFirst Affiliated Hospital of Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac injury is recognized as a major contributor to septic shock and a major component of the multiple organ dysfunction associated with sepsis. Emerging evidence shows that regulation of the intramyocardial oxidative stress and inflammatory response has a promising prospect. Basic fibroblast growth factor (bFGF) exhibits anti-inflammatory and antioxidant properties. In this study, red blood cell membrane-camouflaged poly (lactide-co-glycolide) nanoparticles were synthesized to deliver bFGF (bFGF-RBC/NP) for sepsis-induced cardiac injury. The

Indexed as

basic fibroblast growth factorbiomimetic drug carriercardiac injuryinflammationoxidative stress

Identifiers

PMID35656291
PMCPMC9152292
OpenAlexW4280554811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.