Evidence map›Paper›PMID 35656177›Full record

ArticleIranian journal of basic medical sciences2022

Thiazole derivative based topical nanoemulgel for inhibition of bacterial virulence in surface infections.

Snigdha Bhardwaj, Sonam Bhatia, Pushpraj S Gupta, Shaminder Singh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Snigdha BhardwajDepartment of Pharmaceutical Science, SHALOM Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture.
Sonam BhatiaDepartment of Pharmaceutical Science, SHALOM Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture.
Pushpraj S GuptaDepartment of Pharmaceutical Science, SHALOM Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture.
Shaminder SinghI.T.S College of Pharmacy, Murad Nagar, Ghaziabad, U.P. (201206), India.
Sam Higginbottom Institute of Agriculture · INMotilal Nehru National Institute of Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Antimicrobial resistance emerged as a global challenge owing to limited therapeutic options to control infections. Materials and Methods: Here, we used a structure-based drug design approach to identify lead molecules using the LasR receptor protein of Results: The nanoemulsion (F3) exhibited low droplet size (51.04±1.88 nm), PDI (0.065±1.14), and negative zeta potential (-33.65±0.82 mV). In animals, topical application of NEG-3 demonstrated significant improvement on skin permeability (459±10.17 µg), drug influx (18.99±0.76 μg/cm Conclusion: TC-based NEGs open up the possibility of a more effective way to combat serious surface infections caused by

Indexed as

Anti-virulent strategyDrug-resistanceLasRNanoemulgel formulationPseudomonas aeruginosaThiazole compound

Identifiers

PMID35656177
PMCPMC9148408
OpenAlexW4282947177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.