ArticleIranian journal of basic medical sciences2022
Activation of apoptosis and G0/G1 cell cycle arrest along with inhibition of melanogenesis by humic acid and fulvic acid:
Article in Iranian journal of basic medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Synergistic inhibitory effects of combined liposomal formulations of caffeic acid phenethyl ester and vitamin D on melanoma cell proliferation.Molecular biology reports · 2026Article
- Silencing myeloid cell leukemia-1 improves apoptotic and ferroptotic responses in melanoma.European journal of medical research · 2026Article
- Vitamin D and Inhibition of Melanogenesis: Examination of Liposomal Vitamin D Nanocarrier Anti-Melanogenesis Activity on B16 F10 Cell Line.Food science & nutrition · 2025Article
- Fulvic acid exhibits antitumor effects in ovarian cancer cells by upregulating cytochrome P450 family 1 subfamily A member 1 expression.Discover oncology · 2025Article
- Exploring the Potential Use of Natural Products Together with Alkalization in Cancer Therapy.Pharmaceutics · 2024Review
- IsolatedIranian journal of basic medical sciences · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
Objectives: Humic acid (HA) and Fulvic acid (FA) are major members of humic substances, which are extracted from organic sources including soil and peat. The pro-apoptotic and anti-melanogenic effects of HA and FA at the cellular and molecular levels in the A375 human melanoma cell line were examined in this study. Materials and Methods: The cytotoxicity effect of HA and FA were evaluated by cell viability assay. Apoptosis and cell cycle were investigated by flow cytometry. Real-time PCR was carried out to measure the expression of Results: It was found that HA and FA decrease cell viability with an IC Conclusion: These results exhibited that HA and FA possess pro-apoptotic effects through increasing the
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