Evidence map›Paper›PMID 35656074›Full record

ArticleIranian journal of basic medical sciences2022

Effects of cannabinoid and vanilloid receptor antagonists on nicotine induced relaxation response enhancement in rabbit corpus cavernosum.

Ismail Mert Vural, Gokce Sevi Ozturk Fincan, Derya Sebile Koc, Yagmur Okcay, Celil Ilker Askin, Ayse Kubra Kibar, Sevil Ozger Ilhan, Yusuf Sarioglu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ismail Mert VuralDepartment of Pharmacology, Gulhane Faculty of Pharmacy, University of Health Sciences Turkey, Ankara, Turkey.
Gokce Sevi Ozturk FincanDepartment of Medical Pharmacology, School of Medicine, Gazi University, Ankara, Turkey.
Derya Sebile KocDepartment of Medical Pharmacology, School of Medicine, Gazi University, Ankara, Turkey.
Yagmur OkcayDepartment of Pharmacology, Gulhane Faculty of Pharmacy, University of Health Sciences Turkey, Ankara, Turkey.
Celil Ilker AskinDepartment of Medical Pharmacology, School of Medicine, Gazi University, Ankara, Turkey.
Ayse Kubra KibarDepartment of Medical Pharmacology, School of Medicine, Gazi University, Ankara, Turkey.
Sevil Ozger IlhanDepartment of Medical Pharmacology, School of Medicine, Gazi University, Ankara, Turkey.
Yusuf SariogluDepartment of Medical Pharmacology, School of Medicine, Istinye University, Istanbul, Turkey.
Sağlık Bilimleri Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Endocannabinoids and nicotine regulate the neurotransmitter release in different central and peripheral synapses. Various studies in the literature demonstrate the interaction between endocannabinoid and nicotinic systems, especially in the central nervous system. The interaction between nicotinic and endocannabinoid systems was investigated in this study. We aimed to show the effects of cannabinoid and vanilloid receptor antagonists on nicotine-induced relaxation response increases in rabbit corpus cavernosum. Materials and Methods: From a total of seven male albino rabbits, three or four equal strips were cut from each corpus cavernosum and inserted in isolated organ baths. Tissues were contracted with phenylephrine (3×10 Results: Nicotine (10 Conclusion: In the present study, nicotine increased the amplitudes of EFS-induced relaxation responses probably via nicotinic acetylcholine receptors located on the nitrergic nerves of the corpus cavernosum. We showed the role of cannabinoid-like endo-ligands in nicotine-induced enhancement via CB

Indexed as

Cannabinoid receptorsEndocannabinoidsNicotinePenile erectionSmooth muscle

Identifiers

PMID35656074
PMCPMC9150803
OpenAlexW4282925429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.