Evidence map›Paper›PMID 35655927›Full record

ArticleACS applied nano materials2022

Eutectic Gallium-Indium Nanoparticles for Photodynamic Therapy of Pancreatic Cancer.

Sabrina S Hafiz, Marvin Xavierselvan, Sumeyra Gokalp, Daniela Labadini, Sebastian Barros, Jeanne Duong, Michelle Foster, Srivalleesha Mallidi

Open access · greenAbstract read
In one paragraph

Article in ACS applied nano materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

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  8. The role of corroles in modern cancer therapy: innovation and prospects.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sabrina S HafizDepartment of Chemistry, University of Massachusetts Boston, Boston, Massachusetts 02125, United States.
Marvin XavierselvanDepartment of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, United States.
Sumeyra GokalpDepartment of Chemistry, University of Massachusetts Boston, Boston, Massachusetts 02125, United States.
Daniela LabadiniDepartment of Chemistry, University of Massachusetts Boston, Boston, Massachusetts 02125, United States.
Sebastian BarrosDepartment of Chemistry, University of Massachusetts Boston, Boston, Massachusetts 02125, United States.
Jeanne DuongDepartment of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, United States.
Michelle FosterDepartment of Chemistry, University of Massachusetts Boston, Boston, Massachusetts 02125, United States.ORCID https://orcid.org/0000-0002-5051-2878
Srivalleesha MallidiDepartment of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, United States.ORCID https://orcid.org/0000-0003-1547-1764
University of Massachusetts Boston · USTufts University · US

Funding

U Mass Boston / DFHCC U54 Partnership (1 of 2)U54CA156732 · NCI · DANA-FARBER CANCER INST · PI Nikhil Wagle · 2010 to 2026
$25.6M
Biodegradable liquid metal nanoagents for photoacoustic image-guided photodynamic therapyR21CA263694 · NCI · TUFTS UNIVERSITY MEDFORD · PI MALLIDI, SRIVALLEESHA · 2022 to 2023
$399k
NCI NIH HHS R21 CA263694NCI NIH HHS U54 CA156732
6 · The paper itself

Abstract

Developing a cancer theranostic nanoplatform with diagnosis and treatment capabilities to effectively treat tumors and reduce side effects is of great significance. Herein, we present a drug delivery strategy for photosensitizers based on a new liquid metal nanoplatform that leverages the tumor microenvironment to achieve photodynamic therapeutic effects in pancreatic cancer. Eutectic gallium indium (EGaIn) nanoparticles were successfully conjugated with a water-soluble cancer targeting ligand, hyaluronic acid, and a photosensitizer, benzoporphyrin derivative, creating EGaIn nanoparticles (EGaPs) via a simple green sonication method. The prepared sphere-shaped EGaPs, with a core-shell structure, presented high biocompatibility and stability. EGaPs had greater cellular uptake, manifested targeting competence, and generated significantly higher intracellular ROS. Further, near-infrared light activation of EGaPs demonstrated their potential to effectively eliminate cancer cells due to their single oxygen generation capability. Finally, from

Identifiers

PMID35655927
PMCPMC9150699
OpenAlexW4280596269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.