ArticleChemical science2022
Photoinduced metal-free borylation of aryl halides catalysed by an
Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Metal-free radical borylations: mechanisms, catalytic strategies, and synthetic applications.Chemical science · 2026Review
- Electrochemical desulfurative borylation of thiols, disulfides, thioethers and thioacetals.Nature communications · 2026Article
- Article
- Iodoarene Activation: Take a Leap Forward toward Green and Sustainable Transformations.Chemical reviews · 2025Review
- Photoinduced Site-Selective Aryl C-H Borylation with Electron-Donor-Acceptor Complex Derived from BMolecules (Basel, Switzerland) · 2024Article
- Metal-free visible light mediated direct C-H amination of benzoxazole with secondary amines.Molecular diversity · 2024Article
- Rational design of super reductive EDA photocatalyst for challenging reactions: a theoretical and experimental study.RSC advances · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organoboron compounds are very important building blocks which can be applied in medicinal, biological and industrial fields. However, direct borylation in a metal free manner has been very rarely reported. Herein, we described the successful direct borylation of haloarenes under mild, operationally simple, catalyst-free conditions, promoted by irradiation with visible light. Mechanistic experiments and computational investigations indicate the formation of an excited donor-acceptor complex with a -3.12 V reduction potential, which is a highly active reductant and can facilitate single-electron-transfer (SET) with aryl halides to produce aryl radical intermediates. A two-step one-pot method was developed for site selective aromatic C-H bond borylation. The protocol's good functional group tolerance enables the functionalization of a variety of biologically relevant compounds, representing a new application of aryl radicals merged with photochemistry.
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Registered trials
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