Biomimetic mimicry of formaldehyde-induced DNA-protein crosslinks in the confined space of a metal-organic framework.

Yu-Bai Wei, Dong Luo, Xiao Xiong, Yong-Liang Huang, Mo Xie, Weigang Lu, Dan Li

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Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Yu-Bai WeiCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University Guangzhou 510632 P. R. China weiganglu@jnu.edu.cn danli@jnu.edu.cn.ORCID https://orcid.org/0000-0002-0661-5044

Dong LuoCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University Guangzhou 510632 P. R. China weiganglu@jnu.edu.cn danli@jnu.edu.cn.ORCID https://orcid.org/0000-0001-6960-4783

Xiao XiongCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University Guangzhou 510632 P. R. China weiganglu@jnu.edu.cn danli@jnu.edu.cn.ORCID https://orcid.org/0000-0002-0433-0328

Yong-Liang HuangDepartment of Chemistry, Shantou University Medical College Shantou Guangdong 515041 P. R. China.ORCID https://orcid.org/0000-0003-1569-014X

Mo XieCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University Guangzhou 510632 P. R. China weiganglu@jnu.edu.cn danli@jnu.edu.cn.ORCID https://orcid.org/0000-0001-6721-3711

Weigang LuCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University Guangzhou 510632 P. R. China weiganglu@jnu.edu.cn danli@jnu.edu.cn.ORCID https://orcid.org/0000-0001-9751-8241

Dan LiCollege of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University Guangzhou 510632 P. R. China weiganglu@jnu.edu.cn danli@jnu.edu.cn.ORCID https://orcid.org/0000-0002-4936-4599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA-protein crosslinks (DPCs) are highly toxic DNA lesions induced by crosslinking agents such as formaldehyde (HCHO). Building artificial models to simulate the crosslinking process would advance our understanding of the underlying mechanisms and therefore develop coping strategies accordingly. Herein we report the design and synthesis of a Zn-based metal-organic framework with mixed ligands of 2,6-diaminopurine and amine-functionalized dicarboxylate, representing DNA and protein residues, respectively. Combined characterization techniques allow us to demonstrate the unusual efficiency of HCHO-crosslinking within the confined space of the titled MOF. Particularly,

Identifiers

PMID35655868

DOI10.1039/d2sc00188h

PMCPMC9067591

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