Evidence map›Paper›PMID 35655864›Full record

ArticleChemical science2022

Local detection of pH-induced disaggregation of biocompatible micelles by fluorescence switch ON.

Giulia Battistelli, Maria Proetto, Alexandra Mavridi-Printezi, Matteo Calvaresi, Alberto Danielli, Paolo Emidio Constantini, Claudia Battistella, Nathan C Gianneschi, Marco Montalti

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. pH Switchable Water Dispersed Photocatalytic Nanoparticles.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Giulia BattistelliDepartment of Chemistry "Giacomo Ciamician" Via Selmi 2 Bologna 40126 Italy marco.montalti2@unibo.it.
Maria ProettoDepartment of Chemistry Northwestern University Evanston IL 60208 USA.
Alexandra Mavridi-PrinteziDepartment of Chemistry "Giacomo Ciamician" Via Selmi 2 Bologna 40126 Italy marco.montalti2@unibo.it.ORCID https://orcid.org/0000-0003-1807-4238
Matteo CalvaresiDepartment of Chemistry "Giacomo Ciamician" Via Selmi 2 Bologna 40126 Italy marco.montalti2@unibo.it.ORCID https://orcid.org/0000-0002-9583-2146
Alberto DanielliFaBiT, Department of Pharmacy & Biotechnology, University of Bologna via Selmi 3 40126 Bologna Italy.ORCID https://orcid.org/0000-0002-9414-9898
Paolo Emidio ConstantiniFaBiT, Department of Pharmacy & Biotechnology, University of Bologna via Selmi 3 40126 Bologna Italy.ORCID https://orcid.org/0000-0003-1597-6404
Claudia BattistellaDepartment of Chemistry Northwestern University Evanston IL 60208 USA.ORCID https://orcid.org/0000-0002-5426-6205
Nathan C GianneschiDepartment of Chemistry Northwestern University Evanston IL 60208 USA.ORCID https://orcid.org/0000-0001-9945-5475
Marco MontaltiDepartment of Chemistry "Giacomo Ciamician" Via Selmi 2 Bologna 40126 Italy marco.montalti2@unibo.it.ORCID https://orcid.org/0000-0001-6227-0899
Ospedale San Giacomo Apostolo · ITNorthwestern University · USUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorogenic nanoparticles (NPs) able to sense different physiological environments and respond with disaggregation and fluorescence switching OFF/ON are powerful tools in nanomedicine as they can combine diagnostics with therapeutic action. pH-responsive NPs are particularly interesting as they can differentiate cancer tissues from healthy ones, they can drive selective intracellular drug release and they can act as pH biosensors. Controlled polymerization techniques are the basis of such materials as they provide solid routes towards the synthesis of pH-responsive block copolymers that are able to assemble/disassemble following protonation/deprotonation. Ring opening metathesis polymerization (ROMP), in particular, has been recently exploited for the development of experimental nanomedicines owing to the efficient direct polymerization of both natural and synthetic functionalities. Here, we capitalize on these features and provide synthetic routes for the design of pH-responsive fluorogenic micelles

Identifiers

PMID35655864
PMCPMC9067588
OpenAlexW4226145365

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.