Evidence map›Paper›PMID 35655844›Full record

ArticleQuantitative imaging in medicine and surgery2022

Immuno-PET imaging of PD-L1 expression in patient-derived lung cancer xenografts with [

Qingzhu Liu, Xiaodan Wang, Yanling Yang, Chao Wang, Jian Zou, Jianguo Lin, Ling Qiu

Open access · diamondAbstract read
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
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  4. PET imaging of PD-L1 with a small molecule radiotracer.European journal of nuclear medicine and molecular imaging · 2024
    Article
  5. Review
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  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Qingzhu Liu *NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China.
Xiaodan Wang *Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi, China.
Yanling YangSuzhou Smart Nuclide Biopharmaceutical Co. Ltd., Suzhou Industrial Park, Suzhou, China.
Chao WangSuzhou Smart Nuclide Biopharmaceutical Co. Ltd., Suzhou Industrial Park, Suzhou, China.
Jian ZouCenter of Clinical Research, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Jianguo LinNHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China.
Ling QiuNHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, China.
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology · CNNanjing Medical University · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Accurate evaluation of programmed death-ligand 1 (PD-L1) expression levels in cancer patients may be useful in the identification of potential candidates for anti-programmed death-1/PD-L1 (anti-PD-1/PD-L1) immune checkpoint therapy to improve the response rate of immune checkpoint blockade therapy. This study evaluated the feasibility of the nanobody-based positron emission tomography (PET) tracer [ Methods: We constructed 2 PDXs of lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SCC) and used them for immuno-PET imaging. A 2-hour dynamic PET scanning was performed on the samples and the Results: Noninvasive PET imaging showed that [ Conclusions: This study demonstrated that [

Indexed as

immuno-PET imagingimmunotherapylung cancerpatient-derived xenograft (PDX)PD-L1 expression

Identifiers

PMID35655844
PMCPMC9131318
OpenAlexW4213315514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.