ArticleQuantitative imaging in medicine and surgery2022
Endoscopic optical coherence tomography angiography using inverse SNR-amplitude decorrelation features and electrothermal micro-electro-mechanical system raster scan.
Article in Quantitative imaging in medicine and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 7 citations in OpenAlex.
- Local Birefringence Imaging by Similar Mueller Matrix Averaging Method in Catheter-Based Polarization-Sensitive Optical Coherence Tomography.Chemical & biomedical imaging · 2026Article
- Estimation of Medium Depolarization Index with Noise Immunity in Catheter-Based PS-OCT toward Vascular Plaques Detection.Chemical & biomedical imaging · 2024Article
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5 authors at 3 institutions in 1 country.
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Abstract
Background: Angiogenesis is closely associated with tumor development and progression. Endoscopic optical coherence tomography angiography (OCTA) enables rapid inspection of mucosal 3D vasculature of inner organs in the early-stage tumor diagnosis; however, it is limited by instabilities of the optical signal and beam scanning. Methods: In the phase-unstable swept source OCTA (SS-OCTA), amplitude decorrelation was used to compute the motion-induced changes as motion contrast. The influence of the random noise-induced amplitude fluctuations on decorrelation was characterized as a function of inverse signal-to-noise ratio (SNR) with a multi-variate time series (MVTS) model and statistical analysis. Then, the noise-induced decorrelation artifacts in static tissue regions were eliminated by applying a flow mask based on the statistical relation between inverse SNR (iSNR) and amplitude decorrelation (IDa), which was named IDa-OCTA. In addition, a distal stepwise raster scan was realized with a low-voltage electrothermal micro-electro-mechanical system (ET-MEMS)-based catheter for endoscopic imaging, whereby the stable and repeatable B-scans at each step suppressed the decorrelation noise induced by the spatial mismatch between paired scans. Results: The derived IDa relation was validated through numerical simulation and flow phantom experiments. Conclusions: The rapid 3D vasculature visualization realized by the endoscopic IDa-OCTA improves the diagnosis of early tumors in internal organs.
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