ReviewThe archives of bone and joint surgery2022
How Much Does an Infected Fracture Cost?
Review in The archives of bone and joint surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Intrawound vancomycin powder for infection prophylaxis in definitive fixation of complex fractures: a systematic review and meta-analysis of efficacy and safety.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Pooled it
- Prevention of surgical site infections in lower limb fracture fixation and elective arthroplasty: a systematic review and meta-analysis of decolonization and skin antisepsis strategies.Antimicrobial resistance and infection control · 2026Pooled it
- Optimizing antibiotic prophylaxis for type III open fractures in China: a cost-effectiveness analysis.Health and quality of life outcomes · 2026Article
- Explainable machine learning for perioperative surgical site infection risk enrichment after operative treatment of closed pilon fractures: a multicenter retrospective study with external validation.Frontiers in surgery · 2026Article
- Review
- Dual antibiotic PLGA microspheres for the treatment of traumatic osteomyelitis.Scientific reports · 2025Article
- Early Flap Reconstruction and Infection Rates in Open Lower Extremity Fractures: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2025Article
- Comparing piperacillin/tazobactam to current guidelines for the treatment of open fractures: A systematic review.Journal of orthopaedics · 2025Review
- Article
- Patient-reported outcomes after tibial plateau fracture: infection confers greatest risk of poor outcome.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Article
- The surgical management of fracture-related infection. Surgical strategy selection and the need for early surgical intervention.Journal of orthopaedics · 2024Article
- Predictors of Higher Costs Following Reverse Total Shoulder Arthroplasty.The archives of bone and joint surgery · 2024Article
- Treatment of Fracture-Related Infection after Pelvic Fracture.Journal of clinical medicine · 2023Article
- Incidence of surgical site infection after internal fixation of the first phalangeal bone and the third metacarpal/metatarsal bone fractures in Thoroughbred racehorses.Journal of equine science · 2023Article
- Efficacy and Safety of Antibiotic Impregnated Microporous Nanohydroxyapatite Beads for Chronic Osteomyelitis Treatment: A Multicenter, Open-Label, Prospective Cohort Study.Antibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though infection is a common and costly complication following fracture, there is a scarcity of literature focused on the additional cost of healthcare when a fracture becomes infected. This literature review compiles existing heterogenous data to evaluate the cost of infected fractures, yielding an estimate of a 1.2-fold to six-fold increase in healthcare costs associated with infection. The increases in cost were largely driven by an increased length of stay. Factors which affect this increase include the infectious agent, the depth of infection and the location of the fracture. In order to reduce healthcare costs, early soft tissue cover and prophylactic antibiotics are effective in that they reduce the infection rates. An alternative approach is to reduce the length of stay, the key driver of cost, for example by reducing the length of inpatient antibiotic therapy. Further cost-utility analyses which focus on the same aspects of the healthcare costs are required for a more accurate estimation of the cost.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.