Evidence map›Paper›PMID 35655572›Full record

ArticleChemical science2022

Precisely synthesized segmented polyurethanes toward block sequence-controlled drug delivery.

Yuanqing Song, Chuandong Sun, Chenxu Tian, Hao Ming, Yanjun Wang, Wenkai Liu, Nan He, Xueling He, Mingming Ding, Jiehua Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuanqing SongCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.
Chuandong SunCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.
Chenxu TianCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.
Hao MingCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.
Yanjun WangCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.
Wenkai LiuCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.
Nan HeCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.
Xueling HeLaboratory Animal Center of Sichuan University, Sichuan University Chengdu 610065 China.
Mingming DingCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.ORCID https://orcid.org/0000-0003-2678-6307
Jiehua LiCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.
Feng LuoCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.
Hong TanCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.ORCID https://orcid.org/0000-0002-4614-8276
Qiang FuCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China hongtan@scu.edu.cn dmmshx@scu.edu.cn.ORCID https://orcid.org/0000-0002-5191-3315

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The construction of polyurethanes (PUs) with sequence-controlled block structures remains a serious challenge. Here, we report the precise synthesis of PUs with desirable molecular weight, narrow molecular weight distribution, and controlled block sequences from commercially available monomers. The synthetic procedure is derived from a liquid-phase synthetic methodology, which involves diisocyanate-based iterative protocols in combination with a convergent strategy. Furthermore, a pair of multifunctional PUs with different sequence orders of cationic and anion segments were prepared. We show that the sequence order of functional segments presents an impact on the self-assembly behavior and results in unexpected surface charges of assembled micelles, thereby affecting the protein absorption, cell internalization, biodistribution and antitumor effect of the nanocarriers

Identifiers

PMID35655572
PMCPMC9093123

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.