Evidence map›Paper›PMID 35655524›Full record

ArticleFrontiers in medical technology2022

Guidance for the Interpretation of Continual Cuffless Blood Pressure Data for the Diagnosis and Management of Hypertension.

Josep Sola, Meritxell Cortes, David Perruchoud, Bastien De Marco, Melvin D Lobo, Cyril Pellaton, Gregoire Wuerzner, Naomi D L Fisher, Jay Shah

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in medical technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06446934 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Continual Optical Cuffless Monitoring to Assess the CPAP Therapeutic Effect on Blood Pressure in Obstructive Sleep Apnea Patients

TypeinterventionalSponsorHospital Universitario ArabaRan2024 to 2026Enrolled90ConditionsHypertension, Cardiac Function and Hemodynamics, Usability, Patient ExperienceArmsCPAP
NCT06573801 nacompletednot on this mapstarted 2025, after this paper: background citation

A Single Centre Randomised Prospective Cross-over Study to Assess Agreement Between Blood Pressure Measurements Taken Using Cuffless Wearable and Cuffed, Ambulatory Blood Pressure Monitoring Devices.

TypeinterventionalSponsorQueen Mary University of LondonRan2025 to 2025Enrolled48ConditionsBlood PressureArmsAktiia Bracelet, Healthstats BPro Evo, Spacelabs OnTrak Ambulatory Blood Pressure monitor
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  5. Observational
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  11. Carotid sinus massage in clinical practice.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
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  12. Article
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  15. The future of blood pressure monitoring: what's next?Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Josep SolaAktiia SA, Neuchâtel, Switzerland.
Meritxell CortesAktiia SA, Neuchâtel, Switzerland.
David PerruchoudAktiia SA, Neuchâtel, Switzerland.
Bastien De MarcoAktiia SA, Neuchâtel, Switzerland.
Melvin D LoboBarts NIHR Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Cyril PellatonDivision of Cardiology, Réseau Hospitalier Neuchâtelois (RHNe), Neuchâtel, Switzerland.
Gregoire WuerznerService of Nephrology and Hypertension, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Naomi D L FisherDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, United States.
Jay ShahAktiia SA, Neuchâtel, Switzerland.
Brigham and Women's Hospital · USHospital Neuchâtel · CHMayo Clinic Hospital · USQueen Mary University of London · GBUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension remains the leading risk factor for death worldwide. Despite its prevalence, success of blood pressure (BP) management efforts remains elusive, and part of the difficulty lies in the tool still used to diagnose, measure, and treat hypertension: the sphygmomanometer introduced by Samuel Siegfried Karl von Basch in 1867. In recent years, there has been an explosion of devices attempting to provide estimates of BP without a cuff, overcoming many limitations of cuff-based BP monitors. Unfortunately, the differences in underlying technologies between traditional BP cuffs and newer cuffless devices, as well as hesitancy of changing a well-implemented standard, still generate understandable skepticism about and reluctance to adopt cuffless BP monitors in clinical practice. This guidance document aims to navigate the scientific and medical communities through the types of cuffless devices and present examples of robust BP data collection which are better representations of a person's true BP. It highlights the differences between data collected by cuffless and traditional cuff-based devices and provides an initial framework of interpretation of the new cuffless datasets using, as an example, a CE-marked continual cuffless BP device (Aktiia BP Monitor, Aktiia, Switzerland). Demonstration of novel BP metrics, which have the potential to change the paradigm of hypertension diagnosis and treatment, are now possible for the first time with cuffless BP monitors that provide continual readings over long periods. Widespread adoption of continual cuffless BP monitors in healthcare will require a collaborative and thoughtful process, acknowledging that the transition from a legacy to a novel medical technology will be slow. Finally, this guidance concludes with a call to action to international scientific and expert associations to include cuffless BP monitors in original scientific research and in future versions of guidelines and standards.

Indexed as

blood pressure phenotypecontinuous blood pressurecuffless blood pressuredaytime blood pressurehome blood pressurehypertensionnocturnal blood pressuretime in target range

Identifiers

PMID35655524
PMCPMC9152366
OpenAlexW4280512484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.