Evidence map›Paper›PMID 35655272›Full record

ArticleAntimicrobial resistance and infection control2022

Inappropriate use of antibiotics and its predictors in pediatric patients admitted at the Central Hospital of Nampula, Mozambique.

Sancho Pedro Xavier, Audêncio Victor, Graciano Cumaquela, Melsequisete Daniel Vasco, Osiyallê Akanni Silva Rodrigues

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial resistance and infection control, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Sancho Pedro XavierDepartamento de Farmácia, Faculdade de Ciências de Saúde, Universidade Lúrio, Bairro do Marrere, R. no4250, Nampula, Mozambique. s.xavier@unilurio.ac.mz.ORCID 0000-0001-9493-4098
Audêncio VictorInstituto de Saúde Coletiva, Universidade Federal da Bahia, Rua Basílio da Gama, S/nº Campus Universitário Canela, Salvador, BA, 40110-040, Brazil.
Graciano CumaquelaDepartamento de Farmácia, Faculdade de Ciências de Saúde, Universidade Lúrio, Bairro do Marrere, R. no4250, Nampula, Mozambique.
Melsequisete Daniel VascoInstituto de Saúde Coletiva, Universidade Federal da Bahia, Rua Basílio da Gama, S/nº Campus Universitário Canela, Salvador, BA, 40110-040, Brazil.
Osiyallê Akanni Silva RodriguesInstituto de Saúde Coletiva, Universidade Federal da Bahia, Rua Basílio da Gama, S/nº Campus Universitário Canela, Salvador, BA, 40110-040, Brazil.
Universidade Federal da Bahia · BRLúrio University · MZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntibiotics are synthetic or natural substances used to treat bacterial infectious diseases. When used incorrectly, they can be a factor in the development of antimicrobial resistance, increased treatment time, costs, and mortality. The present study aimed to assess the pattern of inappropriate use of antibiotics and their predictors in pediatric patients admitted to the Central Hospital in Nampula, Mozambique.

methodsA cross-sectional, retrospective study with a quantitative approach was conducted between January and July 2019. The population consisted of children ages 0-10 years hospitalized in the pediatric ward I. Binary logistic regression was used to determine risk factors for the inappropriate use of antibiotics with 95% confidence interval.

resultsThe prevalence of antibiotic use among pediatric patients was 97.5%. Of the 464 antibiotics prescribed, 39.9% were for patients suffering from gastroenteritis, 21.8% and 9.1% for those affected with pneumonia and malaria, respectively. Most antibiotics were for parenteral use (95.9%, 445/464). Many (36.5%) of the prescriptions had errors, primarily in the duration of treatment (74.0%) or dosage (24.4%). Binary logistic regression analysis revealed that patients prescribed ≥ 3 antibiotics (OR = 2.83, 95% CI 1.245-6.462, p-value = 0.013) or hospitalized for a short time (OR = 1.88, 95% CI 1.133-2.3140, p-value = 0.015) were more likely to experience inappropriate use of antibiotics.

conclusionThe study showed both a high prevalence of antibiotic use and a high error rate in prescriptions, especially among patients prescribed ≥ 3 antibiotics or hospitalized for a short time. These results are concerning, since inappropriate and excessive use of antibiotics is a major factor in the development of antibiotic-resistant microorganisms. Therefore, policies to reduce the inappropriate and excessive use of antibiotics are necessary.

Indexed as

Anti-Bacterial AgentsPractice Patterns, Physicians'ChildChild, PreschoolCross-Sectional StudiesDrug PrescriptionsHospitalsHumansInfantInfant, NewbornMozambiqueRetrospective StudiesAnti-Bacterial AgentsAntibiotic prescriptionInappropriate use of antibioticsPediatrics

Identifiers

PMID35655272
PMCPMC9164367
OpenAlexW4281639303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.