Evidence map›Paper›PMID 35655222›Full record

ArticleHarm reduction journal2022

Egocentric network characteristics of people who inject drugs in the Chicago metro area and associations with hepatitis C virus and injection risk behavior.

Mary Ellen Mackesy-Amiti, Joshua Falk, Carl Latkin, Maggie Kaufmann, Leslie Williams, Basmattee Boodram

Abstract read
In one paragraph

Article in Harm reduction journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mary Ellen Mackesy-AmitiDivision of Community Health Sciences, School of Public Health, University of Illinois at Chicago, 1603 W. Taylor St, Chicago, IL, 60612, USA. mmamiti@uic.edu.ORCID http://orcid.org/0000-0002-7238-5240
Joshua FalkAdvanced Cyberinfrastructure for Education and Research (ACER), Office of the Vice Chancellor of Innovation, University of Illinois at Chicago, 728 W. Roosevelt Rd., 215A RRB, Chicago, IL, 60607, USA.
Carl LatkinDepartment of Health, Behavior, and Society, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe St, Baltimore, MD, 21205, USA.
Maggie KaufmannCommunity Outreach Intervention Projects, School of Public Health, University of Illinois at Chicago, 1603 W. Taylor St, Chicago, IL, 60612, USA.
Leslie WilliamsDivision of Community Health Sciences, School of Public Health, University of Illinois at Chicago, 1603 W. Taylor St, Chicago, IL, 60612, USA.
Basmattee BoodramDivision of Community Health Sciences, School of Public Health, University of Illinois at Chicago, 1603 W. Taylor St, Chicago, IL, 60612, USA.

Funding

Computational modeling for HCV vaccine trial design and optimal vaccine-based combination interventionsR01AI158666 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI Basmattee Boodram, Harel Dahari · 2022 to 2026
$3.5M
Contextual risk factors for hepatitis C among young persons who inject drugsR01DA043484 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BOODRAM, BASMATTEE · 2017 to 2021
$2.9M
Computational discovery of effective hepatitis C intervention strategiesR01GM121600 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI BOODRAM, BASMATTEE, DAHARI, HAREL · 2017 to 2021
$2.0M
NIAID NIH HHS R01 AI158666NIDA NIH HHS R01 DA043484NIDA NIH HHS R01DA043484NIGMS NIH HHS R01 GM121600NIGMS NIH HHS R01GM121600
6 · The paper itself

Abstract

backgroundHepatitis C (HCV) infection has been rising in the suburban and rural USA, mainly via injection-based transmission. Injection and sexual networks are recognized as an important element in fostering and preventing risky behavior; however, the role of social support networks has received somewhat less attention.

methodsUsing baseline data from an ongoing longitudinal study, we examined the composition and structure of injection drug use (IDU), sex, and social support networks of young people who inject drugs (aged 18-30) and their injection network members. Lasso logistic regression was used to select a subset of network characteristics that were potentially important predictors of injection risk behaviors and HCV exposure.

resultsSeveral measures of IDU, sexual, and support network structure and composition were found to be associated with HCV exposure, receptive syringe sharing (RSS), and ancillary equipment sharing. Gender and sexual relationships were important factors for all risk behaviors. Support network characteristics were also important, notably including a protective effect of majority Hispanic support networks for RSS and HCV exposure. Both IDU network residence heterogeneity and support network geography were associated with injection equipment sharing.

conclusionsThe associations of IDU and support network geography with equipment sharing highlight the need to extend harm reduction efforts beyond urban areas. Greater understanding of support network influences on risk behavior may provide important insights to strengthen the benefits of harm reduction. In considering the probability of HCV transmission, it is important to consider setting and network structures that promote propagation of risk.

Indexed as

Drug UsersHepatitis CAdolescentChicagoHepacivirusHumansLongitudinal StudiesRisk-TakingEgocentric networksGeographyHepatitis CInjection drug useInjection networkNetwork structurePeople who inject drugsRisk behaviorSupport network

Identifiers

PMID35655222
PMCPMC9161656

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.