Evidence map›Paper›PMID 35655098›Full record

ArticleNature structural & molecular biology2022

Quaternary structure independent folding of voltage-gated ion channel pore domain subunits.

Cristina Arrigoni, Marco Lolicato, David Shaya, Ahmed Rohaim, Felix Findeisen, Lam-Kiu Fong, Claire M Colleran, Pawel Dominik, Sangwoo S Kim, Jonathan P Schuermann and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature structural & molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Deep mutational scan of the pore of the cold-sensing TRPM8 channel.bioRxiv : the preprint server for biology · 2026
    Article
  3. Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Predicting Mutational Effects on CaJournal of the American Chemical Society · 2024
    Article
  6. Advances in CaChannels (Austin, Tex.) · 2023
    Review
  7. EMC chaperone-CaNature · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Cristina ArrigoniCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Marco LolicatoCardiovascular Research Institute, University of California, San Francisco, CA, USA.
David ShayaCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Ahmed RohaimCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Felix FindeisenCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Lam-Kiu FongCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Claire M ColleranCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Pawel DominikDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Sangwoo S KimDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Jonathan P SchuermannNortheastern Collaborative Access Team, Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.
William F DeGradoCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Michael GrabeCardiovascular Research Institute, University of California, San Francisco, CA, USA.ORCID 0000-0003-3509-5997
Anthony A KossiakoffDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Daniel L MinorCardiovascular Research Institute, University of California, San Francisco, CA, USA. daniel.minor@ucsf.edu.ORCID 0000-0002-5998-4214
University of California, San Francisco · USUniversity of Chicago · USCornell University · USQB3 · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Structure and function of voltage-gated calcium channelsR01HL080050 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL L MINOR · 2005 to 2026
$9.8M
Structural Studies of Ion Channel Assembly and Signaling ComplexesR01DC007664 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL L MINOR · 2005 to 2026
$8.2M
Deciphering the relationship between structure, dynamics and function in helical bundle proteinsR35GM122603 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILLIAM DEGRADO · 2017 to 2026
$7.1M
Chaperone-Assisted Structure Determination of Membrane ProteinsR01GM117372 · NIGMS · UNIVERSITY OF CHICAGO · PI ANTHONY A KOSSIAKOFF · 2016 to 2026
$4.0M
Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteinsR01GM137109 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRABE, MICHAEL · 2021 to 2024
$1.4M
Computer simulations of lysosomal and osteoclast microphysiologyR21GM100224 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRABE, MICHAEL · 2012 to 2013
$403k
NHLBI NIH HHS R01 HL080050NIDCD NIH HHS R01 DC007664NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM117372NIGMS NIH HHS R01 GM137109NIGMS NIH HHS R21 GM100224NIGMS NIH HHS R35 GM122603
6 · The paper itself

Abstract

Every voltage-gated ion channel (VGIC) has a pore domain (PD) made from four subunits, each comprising an antiparallel transmembrane helix pair bridged by a loop. The extent to which PD subunit structure requires quaternary interactions is unclear. Here, we present crystal structures of a set of bacterial voltage-gated sodium channel (BacNa

Indexed as

Voltage-Gated Sodium ChannelsMolecular ConformationMolecular Dynamics SimulationVoltage-Gated Sodium Channels

Identifiers

PMID35655098
PMCPMC9809158
OpenAlexW4281738265

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.