ArticleNature metabolism2022
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.
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In one paragraph
Article in Nature metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed, 106 citations in OpenAlex.
- Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026Review
- Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite.The Journal of biological chemistry · 2026Article
- Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026Review
- Innate immunity: current understandings and future perspectives.Signal transduction and targeted therapy · 2026Review
- Metabolomics ofbioRxiv : the preprint server for biology · 2026Article
- Metabolic regulation of macrophage polarization in myocardial infarction: from mechanisms to targeted therapies.Journal of translational medicine · 2026Review
- The lipid A acylation pattern of Coxiella burnetii prevents detection and clearance by the non-canonical inflammasome in primary murine macrophages.PLoS pathogens · 2026Article
- Offense and defense: itaconate mediates bidirectional immune regulation of host-bacteria interaction.Journal of biomedical science · 2026Review
- Identification of a metabolic-immune crosstalk in Still's disease: monocyte/macrophage-derived immunometabolite itaconate dictates hepatic immunopathology via the CXCL10-CD8 T cell axis.Experimental & molecular medicine · 2026Article
- Inhibition of Toxoplasma gondii proliferation by dimethyl itaconate: Evidence from in vitro and in vivo studies.PLoS neglected tropical diseases · 2026Article
- Targeted silencing of CLYBL with platelet-mimetic siRNA nanoparticles drives itaconate-mediated macrophage reprogramming and protects against sepsis-triggered lung cell death.Cell death discovery · 2026Article
- Human pneumovirus induces IFN-dependent expression of the immune-responsive gene 1 and is inhibited by 4-octyl itaconate in human macrophages.NAR molecular medicine · 2026Article
- Article
- Self-actuated probiotic-nanozyme hybrid system with mucus penetration, biofilm eradication and microbiota regulation for Helicobacter pylori infection.Journal of nanobiotechnology · 2026Article
- Mesaconate Alleviates Myocardial Ischemia/Reperfusion Injury and Cardiovascular Aging by Targeting GPR35 to Arrest Macrophage Inflammation.Inflammation · 2026Article
- Molecular Biointerface Characterization for an Implanted Medical Device Using Cryogenic Orbitrap Secondary Ion Mass Spectrometry (Cryo-OrbiSIMS).ACS applied materials & interfaces · 2026Article
- Editorial: Immune cell metabolism beyond energy supply - an emerging era to showcase novel roles in immune effector functions.Frontiers in immunology · 2026Article
- Targeting neuroinflammation: itaconate and mesaconate as therapeutic strategies against H7N7 influenza-associated CNS damage.Frontiers in immunology · 2026Article
- Spatiotemporal profiling of modification-specific proteome secretion uncovers an itaconation-activated tyrosine kinase.Nature communications · 2025Article
- Protective Effect of Mesaconate on Autoimmune Hepatitis via Suppression of Inflammatory Response and Oxidative Stress.Journal of clinical and translational hepatology · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors at 9 institutions in 6 countries.
Wei HeDepartment of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.
Antonia HenneDepartment of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.ORCID http://orcid.org/0000-0001-6870-5312
Mario LauterbachInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany.
Eike GeißmarInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany.
Fabian NikolkaDepartment of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.
Celia KhoInstitute of Experimental Immunology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Alexander HeinzDepartment of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.
Catherine DostertExperimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Melanie GrusdatExperimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Thekla CordesDepartment of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.
Janika HärmDepartment of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany.
Oliver GoldmannInfection Immunology Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Anouk EwenExperimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Charlène VerschuerenExperimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Julia Blay-CadanetDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Robert GeffersGenome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID http://orcid.org/0000-0003-4409-016X
Hendrikus GarritsenInstitute of Transfusion Medicine, Klinikum Braunschweig, Braunschweig, Germany.
Manfred KneilingDepartment of Dermatology, Eberhard Karls University, Tübingen, Germany.
Christian K HolmDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-2655-3362
Christian M MetalloDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-2404-3040
Eva MedinaInfection Immunology Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Zeinab AbdullahInstitute of Experimental Immunology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Eicke LatzInstitute of Innate Immunity, University Hospital Bonn, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-1488-5666
Dirk BrennerExperimental and Molecular Immunology, Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0001-8979-1045
Karsten HillerDepartment of Bioinformatics and Biochemistry, Braunschweig Integrated Centre of Systems Biology (BRICS), Technische Universität Braunschweig, Braunschweig, Germany. karsten.hiller@tu-braunschweig.de.ORCID http://orcid.org/0000-0001-9322-5820
Technische Universität Braunschweig · DEUniversity of Bonn · DEUniversity of Luxembourg · LUHelmholtz Centre for Infection Research · DEAarhus University · DKSalk Institute for Biological Studies · USKlinikum Braunschweig · DESiemens (Germany) · DEUniversity of Southern Denmark · DK
Funding
NHLBI NIH HHS HHSN268201300022C
Abstract
Since its discovery in inflammatory macrophages, itaconate has attracted much attention due to its antimicrobial and immunomodulatory activity
Indexed as
MacrophagesSuccinatesAnimalsInflammasomesMiceRAW 264.7 CellsInflammasomesitaconic acidSuccinates
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.