Evidence map›Paper›PMID 35654975›Full record

ArticleNature genetics2022

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

Marijana Vujkovic, Shweta Ramdas, Kim M Lorenz, Xiuqing Guo, Rebecca Darlay, Heather J Cordell, Jing He, Yevgeniy Gindin, Chuhan Chung, Robert P Myers and 84 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 5 pooled it
27.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 5 syntheses or guidelines pooled it, 181 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Age-Specific Associations of Polygenic Risk Scores With Advanced Fibrosis and Histological Activity in Biopsy-Proven MASLD.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
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  13. Prediagnostic Plasma Metabolite Profiles and Prediction of Hepatocellular Carcinoma Risk: The Multiethnic Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

94 authors at 20 institutions in 4 countries.

Marijana Vujkovic *Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4924-5714
Shweta Ramdas *Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Kim M LorenzCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8674-2942
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-5264-5068
Rebecca DarlayPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Heather J CordellPopulation Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-1879-5572
Jing HeDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Yevgeniy GindinGilead Sciences, Inc., Foster City, CA, USA.
Chuhan ChungGilead Sciences, Inc., Foster City, CA, USA.
Robert P MyersGilead Sciences, Inc., Foster City, CA, USA.
Carolin V SchneiderDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Joseph ParkDepartment of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3313-641X
Kyung Min LeeVA Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-8995-0448
Marina SerperCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Rotonya M CarrDivision of Gastroenterology, University of Washington, Seattle, WA, USA.
David E KaplanCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3839-336X
Mary E HaasBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Matthew T MacLeanDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Walter R WitscheyDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1669-2120
Xiang ZhuVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-1134-6413
Catherine TcheandjieuVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-9559-4339
Rachel L KemberMental Illness Research Education and Clinical Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8820-2659
Henry R KranzlerMental Illness Research Education and Clinical Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1018-0450
Anurag VermaCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
Ayush GiriDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-7786-4670
Derek M KlarinVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-4636-5780
Yan V SunAtlanta VA Medical Center, Decatur, GA, USA.ORCID http://orcid.org/0000-0002-2838-1824
Jie HuangSchool of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, Guangdong, China.ORCID http://orcid.org/0000-0002-9036-4304
Jennifer E HuffmanVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9672-2491
Kate Townsend CreasyDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1870-4586
Nicholas J HandDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8172-1816
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0703-0742
Michelle T LongDepartment of Medicine, Section of Gastroenterology, Boston University School of Medicine, Boston, MA, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Matthew BudoffDepartment of Cardiology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-9616-1946
Jingyi TanThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Xiaohui LiThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Henry J LinThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-6771-0486
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Ruey-Kang ChangThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Ronald M KraussDepartments of Pediatrics and Medicine, University of California, San Francisco, San Francisco, CA, USA.
Silvia VilarinhoSection of Digestive Diseases, Department of Internal Medicine, and Department of Pathology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2099-4212
Joseph BrancaleSection of Digestive Diseases, Department of Internal Medicine, and Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
Jonas B NielsenRegeneron Genetics Center, Tarrytown, NY, USA.
Adam E LockeRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-6227-198X
Marcus B JonesRegeneron Genetics Center, Tarrytown, NY, USA.
Niek VerweijRegeneron Genetics Center, Tarrytown, NY, USA.
Aris BarasRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-6830-3396
K Rajender ReddyDepartment of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Brent A Neuschwander-TetriDepartment of Internal Medicine, Saint Louis University, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-8520-7398
Jeffrey B SchwimmerDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Arun J SanyalDepartment of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Naga ChalasaniDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Kathleen A RyanProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1158-8455
Braxton D MitchellProgram for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Dipender GillDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID http://orcid.org/0000-0001-7312-7078
Andrew D WellsDepartment of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Elisabetta ManduchiDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4110-3714
Yedidya SaimanDepartment of Medicine, Section of Hepatology, Lewis Katz School of Medicine at Temple University, Temple University Hospital, Philadelphia, PA, USA.
Nadim MahmudDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Donald R MillerCenter for Healthcare Organization and Implementation Research, Bedford VA Healthcare System, Bedford, MA, USA.ORCID http://orcid.org/0000-0002-7881-8801
Peter D ReavenPhoenix VA Health Care System, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0001-8923-6690
Lawrence S PhillipsAtlanta VA Medical Center, Decatur, GA, USA.ORCID http://orcid.org/0000-0002-6542-8046
Sumitra MuralidharOffice of Research and Development, Veterans Health Administration, Washington, DC, USA.
Scott L DuVallVA Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-4898-3865
Jennifer S LeeVA Palo Alto Health Care System, Palo Alto, CA, USA.
Themistocles L AssimesVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-2349-0009
Saiju PyarajanVA Boston Healthcare System, Boston, MA, USA.
Kelly ChoVA Boston Healthcare System, Boston, MA, USA.
Todd L EdwardsNashville VA Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-4318-6119
Scott M DamrauerCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8009-1632
Peter W WilsonAtlanta VA Medical Center, Decatur, GA, USA.
J Michael GazianoVA Boston Healthcare System, Boston, MA, USA.
Christopher J O'DonnellVA Boston Healthcare System, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2667-8624
Amit V KheraProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6535-5839
Struan F A GrantDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2025-5302
Christopher D BrownDepartment of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Philip S TsaoVA Palo Alto Health Care System, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-7274-9318
Danish SaleheenDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-6193-020X
Luca A LottaRegeneron Genetics Center, Tarrytown, NY, USA.
Lisa BastaracheDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Quentin M AnsteeFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Ann K DalyNewcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
James B MeigsProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Julie A LynchVA Salt Lake City Health Care System, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-0108-2127
Regeneron Genetics Center
Geisinger-Regeneron DiscovEHR Collaboration
EPoS Consortium
VA Million Veteran Program
Daniel J Rader *Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9245-9876
Benjamin F Voight *Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. bvoight@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-6205-9994
Kyong-Mi Chang *Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. kmchang@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-6811-9364
University of Pennsylvania · USUCLA Medical Center · USPhiladelphia VA Medical Center · USRegeneron (United States) · USBrigham and Women's Hospital · USBroad Institute · USVA Palo Alto Health Care System · USEmory University · USGilead Sciences (United States) · USTranslational Therapeutics (United States) · USVanderbilt University Medical Center · USBoston University · USChildren's Hospital of Philadelphia · USNewcastle University · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBUniversity of Maryland, Baltimore · USUniversity of Massachusetts Lowell · USYale University · USColumbia University Irving Medical Center · USImperial College London · GB

Funding

Glycemia Reduction Approaches in Diabetes: A comparative effectiveness studyU01DK098246 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI KRAUSE-STEINRAUF, HEIDI, LACHIN, JOHN M · 2012 to 2022
$238.9M
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Translational Research Core - Engagement and Behavior ChangeP30DK111024 · NIDDK · EMORY UNIVERSITY · PI Mohammed Kumail Ali · 2016 to 2026
$13.4M
Non Alcoholic Steatohepatitis Clinical Research NetworkU01DK061732 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy · 2002 to 2026
$12.2M
VEDS Year2-Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Data Coordinating CenterU24DK061730 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JEANNE M CLARK, David M Shade · 2019 to 2026
$11.3M
HARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5M
Genome Wide Association Study for Childhood ObesityR01HD056465 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI GRANT, STRUAN F A · 2008 to 2024
$9.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)U01DK061738 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Norah A. Terrault · 2002 to 2026
$8.9M
Functional Interrogation of T2D-associated genes in human stem cell-derived models and miceUM1DK126194 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GRANT, STRUAN F A, KAESTNER, KLAUS H · 2020 to 2024
$8.8M
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
BLRD VA I01 BX003341BLRD VA I01 BX003362BLRD VA I01 BX005831CSRD VA I01 CX001737CSRD VA IK2 CX001780NCATS NIH HHS UL1 TR001878NCATS NIH HHS UL1 TR002378NHGRI NIH HHS K08 HG010155NHGRI NIH HHS U01 HG011719NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL134853NHLBI NIH HHS R01 HL137984NHLBI NIH HHS R01 HL151855NHLBI NIH HHS T32 HL007734NIAAA NIH HHS R01 AA026302NIAID NIH HHS R01 AI123539NIAID NIH HHS R03 AI133172NIAID NIH HHS R21 AI156161NIBIB NIH HHS P41 EB029460NICHD NIH HHS R01 HD056465NIDDK NIH HHS K08 DK124577NIDDK NIH HHS K23 DK113252NIDDK NIH HHS K23 DK115897NIDDK NIH HHS P30 DK111024NIDDK NIH HHS R01 DK101478NIDDK NIH HHS R01 DK114291NIDDK NIH HHS R01 DK122586NIDDK NIH HHS R01 DK127083NIDDK NIH HHS R01 DK131033NIDDK NIH HHS R21 DK099716NIDDK NIH HHS R56 DK101478NIDDK NIH HHS U01 DK061732NIDDK NIH HHS U01 DK061738NIDDK NIH HHS U01 DK078616NIDDK NIH HHS U01 DK098246NIDDK NIH HHS U24 DK061730NIDDK NIH HHS UM1 DK078616NIDDK NIH HHS UM1 DK126194NLM NIH HHS R01 LM010685
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels without other liver diseases, we performed a multiancestry genome-wide association study (GWAS) in the Million Veteran Program (MVP) including 90,408 cALT cases and 128,187 controls. Seventy-seven loci exceeded genome-wide significance, including 25 without prior NAFLD or alanine aminotransferase associations, with one additional locus identified in European American-only and two in African American-only analyses (P < 5 × 10

Indexed as

Genome-Wide Association StudyNon-alcoholic Fatty Liver DiseaseAlanine TransaminaseAlpha-Ketoglutarate-Dependent Dioxygenase FTOHumansIntracellular Signaling Peptides and ProteinsLipaseMembrane ProteinsPolymorphism, Single NucleotideProtein Serine-Threonine KinasesAlanine TransaminaseAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanIntracellular Signaling Peptides and ProteinsLipaseMembrane ProteinsProtein Serine-Threonine KinasesTRIB1 protein, human

Identifiers

PMID35654975
PMCPMC10024253
OpenAlexW4281771922

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.