ArticleNature genetics2022
Genetic correlates of phenotypic heterogeneity in autism.
Abstract read
In one paragraph
Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Does the Extreme Male Brain Hypothesis of Autism Apply More to Females Than Males? A Systematic and Meta-Analytic Approach.Autism research : official journal of the International Society for Autism Research · 2026Pooled it
- Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes.Nature genetics · 2023Pooled it
- Steroid hormone pathways, vitamin D and autism: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2023Pooled it
- A systematic review of non-coding RNA genes with differential expression profiles associated with autism spectrum disorders.PloS one · 2023Pooled it
- Common genetic variants are associated with increased likelihood of latent co-occurring neurodevelopmental and mental health factors among autistic individuals.Molecular psychiatry · 2026Article
- Sex differences in 5-year incidence and prevalence of physical illnesses following early childhood autism diagnosis.JCPP advances · 2026Article
- Uncovering the Role of Biological Sex in the Divergent Genetic Profiles of Early and Late-Diagnosed Autism.Behavior genetics · 2026Article
- Developmental Trajectories of Autistic Traits in Infants With Autism and/or ADHD Family History: Predictors and Mid-Childhood Outcomes.Journal of autism and developmental disorders · 2026Article
- Genetic Heterogeneity in Autism Spectrum Disorder: Diagnostic Yield, Recurrent Genes, and Rare Variant-Phenotype Associations from Whole-Exome Sequencing.International journal of molecular sciences · 2026Article
- Mapping lncRNAs onto multilevel mRNA co‑expression modules in autism.Translational psychiatry · 2026Article
- Childhood trauma as a mediator between autistic traits and depression: Evidence from the ALSPAC birth cohort.Psychological medicine · 2026Article
- Uncovering the Role of Biological Sex in the Divergent Genetic Profiles of Early and Late-Diagnosed Autism.Research square · 2026Article
- The prenatal sex steroid theory of autism after 25 years.Nature human behaviour · 2026Review
- The Genetic Origin of Uneven Cognitive Profiles in Heritable Neurodevelopmental Conditions and Individual Differences: Computational Investigations.Developmental science · 2026Article
- Shared genetic architecture of cortical morphology and psychiatric disorders: insights from a cross-trait analyses across 180 cortical regions.medRxiv : the preprint server for health sciences · 2026Article
- Copper deficiency impairs oligodendrocyte maturation and social behavior via mitophagy and mTOR suppression in ASD.Science advances · 2026Article
- The inactive X chromosome as a female protector in autism and beyond.Nature genetics · 2026Review
- Six artificial intelligence innovation strategies applied to autism spectrum disorder research: A narrative review.Pediatric investigation · 2026Review
- Co-occurrence of rare variants implicates gene pairs in cytoskeletal pathways and is associated with increased severity in autism spectrum disorder.Genome biology · 2026Article
- Mid-childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Varun WarrierAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. vw260@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0003-4532-8571
Xinhe ZhangAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.
Patrick ReedAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.
Alexandra HavdahlNic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-9268-0423
Tyler M MooreDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1384-0151
Freddy CliquetHuman Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, Université de Paris Cité, Paris, France.
Claire S LeblondHuman Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, Université de Paris Cité, Paris, France.
Thomas RollandHuman Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, Université de Paris Cité, Paris, France.
Anders RosengrenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-6682-1288
EU-AIMS LEAP
iPSYCH-Autism Working Group
Spectrum 10K and APEX Consortia
David H RowitchDepartment of Paediatrics, Cambridge University Clinical School, Cambridge, UK.
Matthew E HurlesHuman Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0002-2333-7015
Daniel H GeschwindProgram in Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2896-3450
Anders D BørglumThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-8627-7219
Elise B RobinsonStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Jakob GroveThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-2284-5744
Hilary C MartinHuman Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0002-4454-9084
Thomas BourgeronHuman Genetics and Cognitive Functions, Institut Pasteur, UMR3571 CNRS, Université de Paris Cité, Paris, France.ORCID http://orcid.org/0000-0001-8164-9220
Simon Baron-CohenAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK. sb205@cam.ac.uk.ORCID http://orcid.org/0000-0001-9217-2544
Funding
5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9MDepartment of HealthMedical Research Council MR/N026063/1Medical Research Council MR/W006251/1NIMH NIH HHS U01 MH109514Wellcome TrustWellcome Trust 214322\Z\18\Z
Abstract
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated genetic differences between autistic individuals (n
Indexed as
Autism Spectrum DisorderAutistic DisorderIntellectual DisabilityCognitionFemaleHumansMale
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.