ArticleNature neuroscience2022
Learning binds new inputs into functional synaptic clusters via spinogenesis.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 95 citations in OpenAlex.
- Article
- Ultrastructural Evidence of Altered Dendritic Morphology in the Prefrontal Cortex of Alzheimer's Model Rats.Neuroscience bulletin · 2026Article
- Temporal drift of sleep-wake representations in hypothalamic neuronal ensembles.Nature communications · 2026Article
- Complementary roles of cell-type-specific plasticity in shaping neocortical dynamics for learning action timing.Nature communications · 2026Article
- Learning Shapes the Energy Cost of Neural Tasks.bioRxiv : the preprint server for biology · 2026Article
- Functional organization of dendritic spines in mouse visual cortex layer 2/3 neurons.iScience · 2026Article
- Robust learning-driven structural and functional plasticity of spines in the mature mouse cortex: Robust learning-driven plasticity of spines in the mature cortex.bioRxiv : the preprint server for biology · 2026Article
- Functional synaptic connectivity shapes spine stability in the hippocampus.Nature communications · 2026Article
- Extracellular matrix proteolysis maintains synapse plasticity during brain development.Nature neuroscience · 2026Article
- Semi-automatic geometrical reconstruction and analysis of filopodia dynamics in 4D two-photon microscopy images.BMC bioinformatics · 2026Article
- Article
- Radixin in the nucleus accumbens core modulates amphetamine-induced locomotor activity based on context association.Psychopharmacology · 2025Article
- Article
- Article
- CXCL12 Engages Cortical Inhibitory Neurons to Enhance Dendritic Spine Plasticity and Structured Network Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning.Science (New York, N.Y.) · 2025Article
- Synaptic architecture of a memory engram in the mouse hippocampus.Science (New York, N.Y.) · 2025Article
- Article
- Experience-driven competition in neural reorganization after stroke.The Journal of physiology · 2025Review
- Synaptic facilitation and learning of multiplexed neural signals.Frontiers in network physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Learning induces the formation of new excitatory synapses in the form of dendritic spines, but their functional properties remain unknown. Here, using longitudinal in vivo two-photon imaging and correlated electron microscopy of dendritic spines in the motor cortex of mice during motor learning, we describe a framework for the formation, survival and resulting function of new, learning-related spines. Specifically, our data indicate that the formation of new spines during learning is guided by the potentiation of functionally clustered preexisting spines exhibiting task-related activity during earlier sessions of learning. We present evidence that this clustered potentiation induces the local outgrowth of multiple filopodia from the nearby dendrite, locally sampling the adjacent neuropil for potential axonal partners, likely via targeting preexisting presynaptic boutons. Successful connections are then selected for survival based on co-activity with nearby task-related spines, ensuring that the new spine preserves functional clustering. The resulting locally coherent activity of new spines signals the learned movement. Furthermore, we found that a majority of new spines synapse with axons previously unrepresented in these dendritic domains. Thus, learning involves the binding of new information streams into functional synaptic clusters to subserve learned behaviors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.