ArticleCommunications biology2022
Time-resolved structure-function coupling in brain networks.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.Nature communications · 2026Article
- Review
- Global topology of brain-wide co-fluctuations links task states, personality, and behavioral symptom dimensions.bioRxiv : the preprint server for biology · 2026Article
- Decoupling of neurophysiological activity from structure mirrors global microarchitectural and neuromodulatory trends.Communications biology · 2026Article
- Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026Article
- Introducing Structural Reliance: A New Method to Assess Structure-Function Coupling in the Brain.Human brain mapping · 2026Article
- Cortical gradient compression links cognition and transcriptomic signatures in primary angle-closure glaucoma.Communications biology · 2026Article
- Synapse types are spatially associated with regional hemodynamics in the mouse brain.PLoS biology · 2026Article
- Variation in high-amplitude events across the human lifespan.Network neuroscience (Cambridge, Mass.) · 2026Article
- Impaired connectivity between the thalamus and the visual pathway in schizophrenia: a multimodal magnetic resonance imaging study.Psychoradiology · 2026Article
- Higher-order statistics for constructing centered edge functional connectivity.Network neuroscience (Cambridge, Mass.) · 2026Article
- Diffusion tensor imaging-functional MRI fusion reveals disrupted white matter structure-function coupling in HIV-associated asymptomatic neurocognitive impairment.Frontiers in neuroscience · 2026Article
- Brain network topology and neural mechanisms in Sanda athletes: a comparative study across training levels.Frontiers in neuroscience · 2026Article
- Observational
- Multidimensional structural-functional coupling uncovers network dysregulation and predicts binge-eating severity in bulimia nervosa.BMC medicine · 2025Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- Observational
- Sex effects on dynamic structure-function coupling of intrinsic brain network.Brain imaging and behavior · 2025Article
- Gene transcription, neurotransmitter, and neurocognition signatures of brain structural-functional coupling variability.Nature communications · 2025Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between structural and functional connectivity in the brain is a key question in systems neuroscience. Modern accounts assume a single global structure-function relationship that persists over time. Here we study structure-function coupling from a dynamic perspective, and show that it is regionally heterogeneous. We use a temporal unwrapping procedure to identify moment-to-moment co-fluctuations in neural activity, and reconstruct time-resolved structure-function coupling patterns. We find that patterns of dynamic structure-function coupling are region-specific. We observe stable coupling in unimodal and transmodal cortex, and dynamic coupling in intermediate regions, particularly in insular cortex (salience network) and frontal eye fields (dorsal attention network). Finally, we show that the variability of a region's structure-function coupling is related to the distribution of its connection lengths. Collectively, our findings provide a way to study structure-function relationships from a dynamic perspective.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.