ArticleScientific data2022
A multiscale X-ray phase-contrast tomography dataset of a whole human left lung.
Article in Scientific data, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Computer vision applications for the detection or analysis of tuberculosis using digitised human lung tissue images - a systematic review.BMC medical imaging · 2024Pooled it
- Closing the Loop: High-Precision 3D Photofabrication in Living Tissues.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Next-generation kidney tissue analysis - spatial omics and digital pathology.Nature reviews. Nephrology · 2026Review
- Evolution of hierarchical phase-contrast tomography on the European Synchrotron beamlines BM05 and BM18: a whole adult human brain imaging case study.Journal of synchrotron radiation · 2026Article
- The Extremely Brilliant Brain: An Isotropic Microscale Human Brain Dataset.bioRxiv : the preprint server for biology · 2026Article
- Formaldehyde vapour fixation enables multiscale phase-contrast imaging and histological validation of human-sized lungs.Scientific reports · 2025Article
- Measurements of source emittance and beam coherence properties of the upgraded Advanced Photon Source.Journal of synchrotron radiation · 2025Article
- Tube2FEM: a general-purpose highly automated pipeline for flow-related processes in (embedded) tubular objects.Royal Society open science · 2025Article
- Article
- Real-world federated learning in radiology: hurdles to overcome and benefits to gain.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- 3D digital light process bioprinting: Cutting-edge platforms for resolution of organ fabrication.Materials today. Bio · 2024Review
- Deep learning for 3D vascular segmentation in hierarchical phase contrast tomography: a case study on kidney.Scientific reports · 2024Article
- Synchrotron X-ray imaging of soft biological tissues - principles, applications and future prospects.Journal of cell science · 2024Review
- High-angular-sensitivity X-ray phase-contrast microtomography of soft tissue through a two-directional beam-tracking synchrotron set-up.Journal of synchrotron radiation · 2024Article
- Deep Learning for 3D Vascular Segmentation in Phase Contrast Tomography.Research square · 2024Article
- Multidimensional Analysis of the Adult Human Heart in Health and Disease Using Hierarchical Phase-Contrast Tomography.Radiology · 2024Article
- A closer look at high-energy X-ray-induced bubble formation during soft tissue imaging.Journal of synchrotron radiation · 2024Article
- High-Resolution Phase-Contrast Tomography on Human Collagenous Tissues: A Comprehensive Review.Tomography (Ann Arbor, Mich.) · 2023Review
- Multidimensional Analysis of the Adult Human Heart in Health and Disease using Hierarchical Phase-Contrast Tomography (HiP-CT).bioRxiv : the preprint server for biology · 2023Article
- Preparation of large biological samples for high-resolution, hierarchical, synchrotron phase-contrast tomography with multimodal imaging compatibility.Nature protocols · 2023Review
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 4 countries.
Funding
Abstract
Technological advancements in X-ray imaging using bright and coherent synchrotron sources now allows the decoupling of sample size and resolution while maintaining high sensitivity to the microstructures of soft, partially dehydrated tissues. The continuous developments in multiscale X-ray imaging resulted in hierarchical phase-contrast tomography, a comprehensive approach to address the challenge of organ-scale (up to tens of centimeters) soft tissue imaging with resolution and sensitivity down to the cellular level. Using this technique, we imaged ex vivo an entire human left lung at an isotropic voxel size of 25.08 μm along with local zooms down to 6.05-6.5 μm and 2.45-2.5 μm in voxel size. The high tissue contrast offered by the fourth-generation synchrotron source at the European Synchrotron Radiation Facility reveals the complex multiscale anatomical constitution of the human lung from the macroscopic (centimeter) down to the microscopic (micrometer) scale. The dataset provides comprehensive organ-scale 3D information of the secondary pulmonary lobules and delineates the microstructure of lung nodules with unprecedented detail.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.