Evidence map›Paper›PMID 35654845›Full record

ArticleNature chemical biology2022

A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA.

Yajuan Mu, Lin Zhang, Jingyan Hu, Jiashen Zhou, Hou-Wen Lin, Chuan He, Hong-Zhuan Chen, Liang Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. A distinct subclade of AlkB family demethylases in ciliates safeguards the positional fidelity of eukaryotic NProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Epigenetic Regulation of Fungal Secondary Metabolism.Journal of fungi (Basel, Switzerland) · 2024
    Review
  8. Science advances · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Mammalian DNA NMolecular cell · 2023
    Review
  14. Review
  15. Article
  16. Making a 6mA demethylase.Nature chemical biology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yajuan Mu *Department of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-1759-7291
Lin Zhang *Department of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhanglin777@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-3076-6993
Jingyan Hu *Department of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0003-4212-4741
Jiashen ZhouDepartment of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hou-Wen LinResearch Centre for Marine Drugs, State Key Laboratory of Oncogene and Related Genes, Department of Pharmacy, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-7097-0876
Chuan HeDepartment of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4319-7424
Hong-Zhuan ChenShanghai Frontiers Science Center of Traditional Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China. hongzhuan_chen@hotmail.com.ORCID http://orcid.org/0000-0002-5367-2949
Liang ZhangDepartment of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China. liangzhang2014@sjtu.edu.cn.ORCID http://orcid.org/0000-0002-7672-1168

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

N

Indexed as

DioxygenasesEukaryota5-MethylcytosineAnimalsDNADNA MethylationMammalsMutant Proteins5-MethylcytosineDioxygenasesDNAMutant Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.