ArticleNature cell biology2022
A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression.
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Article in Nature cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
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121citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
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Who cites it
121 citing papers in PubMed, 166 citations in OpenAlex.
- E7386 Enhances Lenvatinib's Antitumor Activity in Preclinical Models and Human Hepatocellular Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Trial
- Second primary cancers following hematologic malignancies: Epidemiology, pathobiology and clinical management.Human vaccines & immunotherapeutics · 2026Review
- A Latent Inflammatory Tissue-State Variable Mechanistically Links Radiotherapy-Induced Immune Remodeling to Recurrent Tumor Permissiveness.bioRxiv : the preprint server for biology · 2026Article
- Cancer-associated fibroblasts drive immune resistance in MSS colorectal cancer via the FAIM2-CES1-ER stress pathway.Molecular and cellular biochemistry · 2026Article
- Integrated pan-cancer analysis reveals a cancer-associated fibroblast oxidative stress response signature predicting immunotherapy response and prognosis.Apoptosis : an international journal on programmed cell death · 2026Article
- Unfolded Protein Response Pathways in Cancer: Mechanisms, Tumor Biology and Therapeutic Opportunities.Molecular diagnosis & therapy · 2026Review
- Single-Cell and Spatial Transcriptomics Reframe the Immunosuppressive Microenvironment of Neuroendocrine Neoplasms.Cancers · 2026Review
- Psoriasis-Obesity-Related Gene COX7C Promotes Keratinocyte Proliferation and Positively Regulates Inflammatory Responses in Psoriasis.Journal of cellular and molecular medicine · 2026Article
- Integrated stress response couples mitochondrial fitness with lineage reprogramming to drive cancer evolution.Nature cell biology · 2026Article
- Heterogeneity of cancer-associated fibroblast subtypes in the prostate cancer microenvironment and their clinical implications: prognostic model construction and therapeutic target exploration based on bioinformatics analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Upregulation of ADAM19 in dendritic cells is associated with immune features and lower C-peptide levels in type 1 diabetes mellitus.Diabetology & metabolic syndrome · 2026Article
- The remarkable legacy of the K6/ODC mouse: mechanisms of polyamine-promoted tumorigenesis revealed.Amino acids · 2026Review
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- Radiation-induced autophagy regulates fibroblast mitochondrial metabolism and crosstalk with triple-negative breast cancer cells.Cell reports · 2026Article
- Utilizing bulk and single-cell RNA sequencing to identify potential biomarkers linked to angiogenesis and integrated stress response in chondrosarcoma.Scientific reports · 2026Article
- SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids.NPJ Parkinson's disease · 2026Article
- Obstacles and improvement strategies for CAR-T cell therapy in solid tumors.Discover oncology · 2026Review
- GLUL Confers Perivascular Cancer-Associated Fibroblasts With Pro-Angiogenic Capacity to Promote Glioma Progression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell multiome and enhancer connectome of human retinal pigment epithelium and choroid nominate causal variants in macular degeneration.Cell reports · 2026Article
61 more citing papers are in PubMed but not listed here.
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Authors and funding
33 authors at 9 institutions in 3 countries.
Ioannis I VerginadisDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Harris AvgoustiDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
James MonslowDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Giorgos SkoufosDepartment of Electrical and Computer Engineering, University of Thessaly, Volos, Greece.ORCID http://orcid.org/0000-0001-9022-6334
Frank ChingaDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Kyle KimDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nektaria Maria LeliDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ilias V KaragounisDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Brett I BellDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-8439-1402
Anastasia VelalopoulouDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Carlo Salas SalinasDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Victoria S WuDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yang LiDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
Jiangbin YeDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1117-4869
David A ScottCancer Metabolism Core, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8668-2449
Andrei L OstermanCancer Metabolism Core, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Arjun SenguptaDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Aalim WeljieDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Menggui HuangDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4942-5558
Duo ZhangDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3215-2466
Yi FanDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Enrico RadaelliDepartment of Pathobiology, School of Veterinary Medicine, Comparative Pathology Core, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2885-0221
John W TobiasPenn Genomic Analysis Core, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Florian RambowLaboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium.
Panagiotis KarrasLaboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-7642-0875
Jean-Christophe MarineLaboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2433-9837
Xiaowei XuDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Artemis G HatzigeorgiouDepartment of Electrical and Computer Engineering, University of Thessaly, Volos, Greece.
Sandra RyeomDepartment of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9869-4455
J Alan DiehlDepartment of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-9854-5049
Serge Y FuchsDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0136-5103
Ellen PuréDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Constantinos KoumenisDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. costas.koumenis@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-5945-4726
University of Pennsylvania · USVIB-KU Leuven Center for Cancer Biology · BESanford Burnham Prebys Medical Discovery Institute · USStanford University · USTranslational Therapeutics (United States) · USUniversity of Thessaly · GRAlbert Einstein College of Medicine · USCase Western Reserve University · USColumbia University Irving Medical Center · US
Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Michael Jackson · 1985 to 2026
$107.2MPhenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MTumor Assessment CoreP01CA128814 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI SMITH, JEFFREY W · 2009 to 2020
$19.1MUPR, interferon signaling and tumorigenesisP01CA165997 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KOUMENIS, CONSTANTINOS · 2013 to 2023
$10.9MProject 3 - Immune analysis of clinical trial samplesP01CA217805 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HWANG, WEI-TING · 2018 to 2022
$10.4MSUMMER UNDERGRADUATE PROGRAM TO EDUCATE RADIATION SCIENTISTS (SUPERS)R25CA140116 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JAY FITZGERALD DORSEY · 2010 to 2026
$4.1MNegative Regulation of VEGF-Mediated AngiogenesisR01CA118374 · NCI · UNIVERSITY OF PENNSYLVANIA · PI RYEOM, SANDRA · 2009 to 2019
$3.4MThe integrated stress response and the microenvironment in melanoma progressionR01CA268597 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Colin Goding, Constantinos Koumenis · 2022 to 2026
$2.0MNCATS NIH HHS UL1 TR001878NCI NIH HHS P01 CA128814NCI NIH HHS P01 CA165997NCI NIH HHS P01 CA217805NCI NIH HHS P30 CA030199NCI NIH HHS R01 CA118374NCI NIH HHS R01 CA268597NCI NIH HHS R25 CA140116
Abstract
Bidirectional signalling between the tumour and stroma shapes tumour aggressiveness and metastasis. ATF4 is a major effector of the Integrated Stress Response, a homeostatic mechanism that couples cell growth and survival to bioenergetic demands. Using conditional knockout ATF4 mice, we show that global, or fibroblast-specific loss of host ATF4, results in deficient vascularization and a pronounced growth delay of syngeneic melanoma and pancreatic tumours. Single-cell transcriptomics of tumours grown in Atf4
Indexed as
Cancer-Associated FibroblastsMelanomaPancreatic NeoplasmsAnimalsCollagenFibroblastsGene Expression Regulation, NeoplasticMiceMice, KnockoutNeovascularization, PathologicCollagen
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