ArticleNPJ Parkinson's disease2022
Validation of the PD home diary for assessment of motor fluctuations in advanced Parkinson's disease.
Article in NPJ Parkinson's disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Mesdopetam for the Treatment of Levodopa Induced Dyskinesia in Parkinson's Disease: A Randomized Phase 2b Trial.Movement disorders clinical practice · 2025Trial
- On-demand therapies-emergency medication or daily routine?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- NeuroSift for Task-Aware Quality Assurance of Multimedia Data in Remote Parkinson Disease Assessment: Machine Learning Model Development and Validation Study.Journal of medical Internet research · 2026Article
- Frequency and types of motor fluctuations in patients presenting with advanced Parkinson's disease.Pakistan journal of medical sciences · 2026Article
- Weekly Variability of an Objective Bradykinesia Score in Parkinson's Disease-An Observational Longitudinal Study.Journal of clinical medicine · 2026Article
- Identification of responsive motor symptom assessment items reflecting plasma levodopa changes in individuals with Parkinson's disease.Clinical parkinsonism & related disorders · 2026Article
- Compliance and Satisfaction for 16 months of Adapted Tango vs. Supervised Walking for People with Parkinson's.NPJ Parkinson's disease · 2025Article
- Codeine as a Potential Drug Against Motor Symptoms in Parkinson's Disease: Report of Two Cases.Cureus · 2025Article
- Parkinson's disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial.NPJ Parkinson's disease · 2025Article
- Levodopa-Entacapone-Carbidopa Intrajejunal Infusion in Advanced Parkinson's Disease - Interim Analysis of the ELEGANCE Study.Movement disorders clinical practice · 2025Article
- Determinants of Adherence and Satisfaction in Parkinson's Disease Exercise Programs: A Comparison of 16-Months of Adapted Tango vs. Supervised Walking.Research square · 2025Article
- Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain-Sense Study.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Detecting Freezing of Gait in Parkinson Disease Using Multiple Wearable Sensors Sets During Various Walking Tasks Relative to Medication Conditions (DetectFoG): Protocol for a Prospective Cohort Study.JMIR research protocols · 2025Article
- Perspectives on digital health and advanced treatment referral in Parkinson's care among Danish neurologists: a mixed methods study.Frontiers in neurology · 2025Article
- Evaluation of compliance and accuracy in Parkinson's disease motor symptom tracking: a comparative study of digital and traditional paper diaries using a smartphone application (MyParkinson's).Frontiers in neurology · 2025Article
- Safinamide as an adjunct to levodopa monotherapy in Asian patients with Parkinson's disease experiencing early wearing-off: a pooled analysis of the J-SILVER and KEEP studies.Frontiers in neurology · 2025Article
- Outcome Selection for Research Studies in Movement Disorders.Movement disorders clinical practice · 2024Article
- Validity and Reliability of the Korean Versions of the 9- and 19-Item Wearing-Off Questionnaires in Parkinson's Disease.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Interpretable video-based tracking and quantification of parkinsonism clinical motor states.NPJ Parkinson's disease · 2024Article
- Complexities and challenges of translating intervention success to real world gait in people with Parkinson's disease.Frontiers in neurology · 2024Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Parkinson's disease (PD) home diary is frequently used in clinical trials to measure efficacy of medical treatments for motor fluctuations in advanced PD. This prospective study in fluctuating PD patients examines the validity of the diary for quantification of motor states in comparison to direct clinical observation. 51 patients (median age: 65 years, disease duration: 11 years) completed the diary half-hourly for two consecutive days and were simultaneously rated by an experienced observer, who independently evaluated motor states half-hourly throughout daytime. Overall agreement (Cohen's kappa) between patient and observer diary entries was 59.8% (0.387). Patients documented more On without dyskinesia (52.3% vs. 38.9%, P < 0.001) and less On with dyskinesia (21.5% vs. 34.2%, P < 0.001), whereas proportions for Off intervals were not different between patient and observer diaries (26.2% vs. 27.0%, P = 0.97). Temporal agreement between diary ratings was unsatisfactory, particularly for On with dyskinesia. Taken together, our study suggests that the PD home diary only inadequately reflects actual motor states compared to direct clinical observation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.