Evidence map›Paper›PMID 35654771›Full record

Trial reportNutrition & diabetes2022

Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention.

Katelyn E Senkus, Kristi M Crowe-White, Anneliese C Bolland, Julie L Locher, Jamy D Ard

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition & diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00955903 (Calorie Restriction and Changes in Body Composition, Disease, Function, and Quality of Life in Older Adults), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00955903 phase3completednot on this map

Calorie Restriction and Changes in Body Composition, Disease, Function, and Quality of Life in Older Adults

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2010 to 2014Enrolled167ConditionsObesity, Diabetes, Hypertension, HyperlipidemiaArmsExercise, Reduced Calorie Diet, Weight Maintenance Diet
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  11. Cancer-Associated Cachexia in the Era of Obesity.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Katelyn E SenkusDepartment of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA.ORCID 0000-0002-1711-398X
Kristi M Crowe-WhiteDepartment of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA. kcrowe@ches.ua.edu.ORCID 0000-0003-2497-4582
Anneliese C BollandCollege of Communication and Information Sciences, Communication Studies & Institute for Communication and Information Research, The University of Alabama, Tuscaloosa, AL, USA.
Julie L LocherDivision of Gerontology, Geriatrics and Palliative Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jamy D ArdWake Forest University School of Medicine, Department of Epidemiology and Prevention, Winston-Salem, NC, USA.
University of Alabama · USUniversity of Alabama at Birmingham · USWake Forest University · US

Funding

Calorie Restriction & Changes in Body Composition, Disease, Function, & QoL in OlR01AG033094 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ARD, JAMY D, LOCHER, JULIE L. · 2009 to 2013
$2.8M
NIA NIH HHS R01 AG033094
6 · The paper itself

Abstract

backgroundExcess adiposity is characterized by alterations in adipokine secretion such that circulating leptin concentrations are increased with reductions in adiponectin. An emerging biomarker for the assessment of this adipose tissue (AT) dysfunction is the adiponectin:leptin (AL) ratio. A low AL ratio may be suggestive of dysfunctional AT and, consequently, a heightened cardiometabolic disease risk. This ancillary study investigated the relationship between the AL ratio and cardiometabolic health among community-dwelling older adults with obesity, as well as the effects of a 12-month exercise and diet intervention on changes in the AL ratio.

methodsParticipants (n = 163, 70.2 ± 4.7 years, 38.0% male) were randomized to the exercise only group, exercise + nutrient-dense weight maintenance group (exercise + weight maintenance), or exercise + nutrient-dense caloric restriction of 500 kcal/d group (exercise + intentional weight loss) (clinicaltrials.gov #NCT00955903). Total and regional adiposity as determined by magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA), anthropometrics, and cardiometabolic biomarkers were assessed at baseline and 12 months.

resultsThe AL ratio was significantly (p < 0.05) inversely correlated with body mass index, waist circumference, measures of adiposity, and insulin among all participants at baseline. Among females only, significant positive and inverse correlations were also observed between this ratio and high-density lipoprotein cholesterol and the inflammatory biomarkers high sensitivity C-reactive protein and interleukin-6, respectively. While controlling for biological sex, a significant time by intervention group interaction effect (p < 0.05) was observed such that the AL ratio significantly increased from baseline to study completion among participants in the exercise + weight maintenance group and exercise + intentional weight loss group. Post hoc analysis revealed that the exercise + intentional weight loss group exhibited a significantly greater AL ratio at study completion compared to other groups (p < 0.05 all).

conclusionsResults are in support of the AL ratio as a measure of AT dysfunction among older adults. Furthermore, results suggest that a 12-month exercise and diet intervention with intentional weight loss assists in improving the AL ratio in this population.

Indexed as

Cardiovascular DiseasesLeptinAdiponectinAgedBiomarkersDiet, ReducingFemaleHumansMaleObesityWeight LossAdiponectinBiomarkersLeptin

Identifiers

PMID35654771
PMCPMC9163185
OpenAlexW4281835703

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.