ArticleJournal of the American Society of Nephrology : JASN2022
Coronary Artery Calcification Score and the Progression of Chronic Kidney Disease.
Article in Journal of the American Society of Nephrology : JASN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Cardiovascular Disease in CKD: Ethnic and Regional Differences in Risk and Phenotype.Clinical journal of the American Society of Nephrology : CJASN · 2026Review
- PKM2 AP: a micropeptide inhibits vascular calcification via molecular glue-mediated ubiquitination of PKM2.Nature communications · 2026Article
- Coronary artery calcium and multiparametric cardiovascular risk assessment in non-dialysis chronic kidney disease.Biomolecules & biomedicine · 2026Article
- Association between deep learning-based coronary artery calcium score on non-gated chest CT and progression of chronic kidney disease: a retrospective observational cohort study.BMC medical imaging · 2026Observational
- Does Atherosclerosis Progress Faster After Liver Transplant? A Comparative Study and Analysis of Progression Risk Factors.Journal of transplantation · 2026Article
- Ratio of extracellular water and body cell mass is associated with coronary artery calcification in peritoneal dialysis patients.Frontiers in medicine · 2026Article
- Decoding Vascular Senescence: Cellular Insights and Therapeutic Strategies.International journal of biological sciences · 2026Review
- Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis.Renal failure · 2025Article
- Type 2 diabetes mellitus modifies the relationship between coronary artery calcification and adverse kidney outcome in patients with chronic kidney disease: the findings from KNOW-CKD.Journal of nephrology · 2025Article
- Pulse wave-driven machine learning for the non-invasive assessment of coronary artery calcification in patients with end-stage renal disease undergoing hemodialysis.Biomedical engineering online · 2025Article
- Study on the relationship between in-stent neoatherosclerosis and chronic kidney disease: an optical coherence tomography study.Scientific reports · 2025Article
- Correlation between coronary calcification and cardiac structure in non-dialysis patients with chronic kidney disease.ESC heart failure · 2025Article
- The Agatston score is a predictor of contrast-induced nephropathy in patients with stable coronary artery disease after percutaneous coronary intervention.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2024Article
- Histone deacetylase 9 promotes osteogenic trans-differentiation of vascular smooth muscle cells via ferroptosis in chronic kidney disease vascular calcification.Renal failure · 2024Article
- Association of serum HIF-1α levels with coronary artery calcification in patients of non-dialysis chronic kidney disease.Scientific reports · 2024Article
- Impact of Arterial Calcification on Cardiovascular and Renal Outcomes in Kidney Transplant Patients.Kidney diseases (Basel, Switzerland) · 2024Article
- Triglyceride-glucose index is an independent predictor of coronary artery calcification progression in patients with chronic kidney disease.Kidney research and clinical practice · 2024Article
- Association between the neutrophil-to-lymphocyte ratio and in-hospital mortality in patients with chronic kidney disease and coronary artery disease in the intensive care unit.European journal of medical research · 2024Article
- The Associations Between Abdominal Obesity and Coronary Artery Calcification in Chronic Kidney Disease Population.International journal of nephrology and renovascular disease · 2024Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn elevated coronary artery calcification score (CACS) is associated with increased cardiovascular disease risk in patients with CKD. However, the relationship between CACS and CKD progression has not been elucidated.
methodsWe studied 1936 participants with CKD (stages G1-G5 without kidney replacement therapy) enrolled in the KoreaN Cohort Study for Outcome in Patients With CKD. The main predictor was Agatston CACS categories at baseline (0 AU, 1-100 AU, and >100 AU). The primary outcome was CKD progression, defined as a ≥50% decline in eGFR or the onset of kidney failure with replacement therapy.
resultsDuring 8130 person-years of follow-up, the primary outcome occurred in 584 (30.2%) patients. In the adjusted cause-specific hazard model, CACS of 1-100 AU (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.04 to 1.61) and CACS >100 AU (HR, 1.42; 95% CI, 1.10 to 1.82) were associated with a significantly higher risk of the primary outcome. The HR associated with per 1-SD log of CACS was 1.13 (95% CI, 1.03 to 1.24). When nonfatal cardiovascular events were treated as a time-varying covariate, CACS of 1-100 AU (HR, 1.31; 95% CI, 1.07 to 1.60) and CACS >100 AU (HR, 1.46; 95% CI, 1.16 to 1.85) were also associated with a higher risk of CKD progression. The association was stronger in older patients, in those with type 2 diabetes, and in those not using antiplatelet drugs. Furthermore, patients with higher CACS had a significantly larger eGFR decline rate.
conclusionOur findings suggest that a high CACS is associated with significantly increased risk of adverse kidney outcomes and CKD progression.
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