Evidence map›Paper›PMID 35654455›Full record

ArticleGenes & development2022

The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination.

Yongqiang Gao, Rocio Del Carmen Barajas-Ornelas, Jeremy D Amon, Fernando H Ramírez-Guadiana, Assaf Alon, Kelly P Brock, Debora S Marks, Andrew C Kruse, David Z Rudner

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 40 citations in OpenAlex.

  1. mBio · 2026
    Article
  2. Article
  3. Article
  4. bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Newly identified SpoVAF/FigP complex: the role inApplied and environmental microbiology · 2025
    Article
  12. Identification and characterization of theJournal of bacteriology · 2024
    Article
  13. Article
  14. The megaplasmid pCER270 ofApplied and environmental microbiology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yongqiang GaoDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Rocio Del Carmen Barajas-OrnelasDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Jeremy D AmonDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA.ORCID 0000-0002-8748-5228
Fernando H Ramírez-GuadianaDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Assaf AlonDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Kelly P BrockDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Debora S MarksDepartment of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Andrew C KruseDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
David Z RudnerDepartment of Microbiology, Harvard Medical School, Boston, Massachusetts 02115, USA.ORCID 0000-0002-0236-7143
Harvard University · USBroad Institute · US

Funding

Chromosome Dynamics in Bacillus SubtillsR01GM086466 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2009 to 2021
$4.2M
Molecular basis of spore germinationR01AI164647 · NIAID · HARVARD MEDICAL SCHOOL · PI Andrew Kruse, DAVID Z RUDNER · 2022 to 2026
$4.2M
Cell Envelope Homeostasis in Bacillus subtilisR01GM127399 · NIGMS · HARVARD MEDICAL SCHOOL · PI RUDNER, DAVID Z · 2019 to 2022
$1.4M
Molecular Mechanisms of Spore GerminationF32GM130003 · NIGMS · HARVARD MEDICAL SCHOOL · PI AMON, JEREMY DAVID · 2018 to 2021
$223k
NIAID NIH HHS R01 AI164647NIGMS NIH HHS F32 GM130003NIGMS NIH HHS R01 GM086466NIGMS NIH HHS R01 GM127399
6 · The paper itself

Abstract

In response to starvation, endospore-forming bacteria differentiate into stress-resistant spores that can remain dormant for years yet rapidly germinate and resume growth in response to nutrients. The small molecule dipicolinic acid (DPA) plays a central role in both the stress resistance of the dormant spore and its exit from dormancy during germination. The

Indexed as

Bacterial ProteinsSpores, BacterialBacillus subtilisPicolinic AcidsBacterial Proteinsdipicolinic acidPicolinic Acidsdipicolinic aciddormancyDPAgerminationsporulationspoVA

Identifiers

PMID35654455
PMCPMC9186386
OpenAlexW4281622106

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.