Trial reportThe journal of allergy and clinical immunology. In practice2022
Constant-Load Exercise Versus High-Intensity Interval Training on Aerobic Fitness in Moderate-to-Severe Asthma: A Randomized Controlled Trial.
Trial report in The journal of allergy and clinical immunology. In practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Methodological and aerobic capacity adaptations of high-intensity interval training at different altitudes in distance runners: A comprehensive meta-analysis.Physiological reports · 2025Pooled it
- Pooled it
- Rehabilitation effects of high-intensity interval training on asthma: a systematic review and meta-analysis of randomized controlled trials.Journal of thoracic disease · 2026Article
- Effect of physical activity on pulmonary function and quality of life in asthma patients: a systematic review and meta-analysis.Frontiers in medicine · 2026Review
- Mechanistic advances in the regulation of asthma by different exercise modalities: an integrative perspective on exercise load characteristics and asthma heterogeneity.Frontiers in physiology · 2026Review
- Effects of Aerobic Training Versus Behavioral Intervention to Increase Physical Activity for Disease Control in Patients With Asthma: Protocol for a Randomized Trial.JMIR research protocols · 2025Article
- Exercise Recommendations and Practical Considerations for Asthma Management-An EAACI Position Paper.Allergy · 2025Article
- Comprehensive exercise program based on optimal physiotherapy for asthma-related quality of life: a systematic review and network meta-analysis.Frontiers in sports and active living · 2025Review
- Patient-centred outcomes in severe asthma: fatigue, sleep, physical activity and work.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- ERS International Congress 2023: highlights from the Respiratory Clinical Care and Physiology Assembly.ERJ open research · 2024Article
- Effects of constant-load exercise and high-intensity interval training on reliever medication consumption and peak expiratory flow in individuals with asthma: a randomised controlled trial.ERJ open research · 2024Article
- Physical training in adults with asthma: An integrative approach on strategies, mechanisms, and benefits.Frontiers in rehabilitation sciences · 2023Review
- Characteristics of individuals with moderate to severe asthma who better respond to aerobic training: a cluster analysis.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2023Article
- Exercising with Asthma: A Slow Burn or a Quick HIIT?The journal of allergy and clinical immunology. In practice · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of high-intensity interval training (HIIT) on dyspnea and aerobic fitness in adults with asthma are poorly understood.
objectiveTo compare constant-load exercise (CLE) versus HIIT for improvements in dyspnea symptoms and clinical control in adults with moderate-to-severe asthma.
methodsParticipants were randomized into 2 groups: CLE (n = 27; started with 70% of maximal watts [Wmax] obtained during cardiopulmonary exercise testing [CPET]) and HIIT (n = 28; started with 80% and increased until 140% Wmax). Exercise training lasted 12 weeks (twice/week, 40 minutes/session on a cycle ergometer), and the intensity was based on CPET. Clinical asthma control (Asthma Control Questionnaire), aerobic fitness (the peak of oxygen uptake), health-related quality of life (Asthma Quality of Life Questionnaire), physical activity levels (PAL; accelerometer), symptoms of anxiety and depression (Hospital Anxiety and Depression Scale questionnaire), and dyspnea were evaluated before and after the intervention. Systemic and airway inflammation were also assessed. Two-way analysis of variance and χ
resultsThe CLE and HIIT groups showed similar improvements in aerobic fitness. The HIIT group had lower dyspnea and fatigue perception scores and higher PAL than the CLE group (P < .05) and clinical improvements in the psychosocial distress. In addition, only the HIIT group achieved a minimal clinically important difference in asthma symptoms. There was no change in the systemic and airway inflammation (P > .05).
conclusionBoth interventions promoted similar improvements in aerobic fitness; however, HIIT induced a greater reduction in dyspnea and fatigue perception. Similar responses were observed for other variables.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.