Evidence map›Paper›PMID 35654121›Full record

ArticleAmerican journal of ophthalmology2022

Race and Ethnicity Differences in Disease Severity and Visual Field Progression Among Glaucoma Patients.

Omar A Halawa, Qingying Jin, Louis R Pasquale, Jae H Kang, Alice C Lorch, Lucia Sobrin, Joan W Miller, Yangjiani Li, Mohammad Eslami, Mengyu Wang and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Omar A HalawaFrom the Department of Ophthalmology, Massachusetts Eye and Ear/Mass General Brigham, Harvard Medical School, Boston, MA, USA (O.A.H, A.C.L, L.S, J.W.M, N.Z).
Qingying JinDepartment of Psychology, School of Philosophy and Sociology, Jilin University, Changchun, Jilin, China (Q.J); Schepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA (Q.J, Y.L, M.E, M.W, T.E).
Louis R PasqualeDepartment of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA (L.R.P).
Jae H KangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA (J.H.K).
Alice C LorchFrom the Department of Ophthalmology, Massachusetts Eye and Ear/Mass General Brigham, Harvard Medical School, Boston, MA, USA (O.A.H, A.C.L, L.S, J.W.M, N.Z).
Lucia SobrinFrom the Department of Ophthalmology, Massachusetts Eye and Ear/Mass General Brigham, Harvard Medical School, Boston, MA, USA (O.A.H, A.C.L, L.S, J.W.M, N.Z).
Joan W MillerFrom the Department of Ophthalmology, Massachusetts Eye and Ear/Mass General Brigham, Harvard Medical School, Boston, MA, USA (O.A.H, A.C.L, L.S, J.W.M, N.Z).
Yangjiani LiSchepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA (Q.J, Y.L, M.E, M.W, T.E).
Mohammad EslamiSchepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA (Q.J, Y.L, M.E, M.W, T.E).
Mengyu WangSchepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA (Q.J, Y.L, M.E, M.W, T.E).
Nazlee ZebardastFrom the Department of Ophthalmology, Massachusetts Eye and Ear/Mass General Brigham, Harvard Medical School, Boston, MA, USA (O.A.H, A.C.L, L.S, J.W.M, N.Z).
Tobias ElzeSchepens Eye Research Institute of Mass Eye and Ear, Harvard Medical School, Boston, MA, USA (Q.J, Y.L, M.E, M.W, T.E). Electronic address: tobias_elze@meei.harvard.edu.
Massachusetts Eye and Ear Infirmary · USBrigham and Women's Hospital · USIcahn School of Medicine at Mount Sinai · US

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
Gene-Environment Interactions in GlaucomaR01EY015473 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI PASQUALE, LOUIS ROBERT · 2005 to 2021
$8.3M
Understanding the clinical impact of cumulative genetic risk to glaucomaR01EY032559 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Louis Robert Pasquale, Janey L Wiggs · 2021 to 2026
$4.3M
Personalizing Glaucoma Diagnosis by Disease Specific Patterns and Individual Eye AnatomyR01EY030575 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI ELZE, TOBIAS · 2019 to 2023
$2.4M
Glaucoma Risk Prediction Using Machine Learning Integration of Image-Based Phenotypes and Genetic AssociationsK23EY032634 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI ZEBARDAST, NAZLEE · 2021 to 2024
$1.0M
Relationship between Glaucoma and the Three-Dimensional Optic Nerve Head Related StructureR00EY028631 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI WANG, MENGYU · 2021 to 2023
$741k
NEI NIH HHS K23 EY032634NEI NIH HHS P30 EY003790NEI NIH HHS R00 EY028631NEI NIH HHS R01 EY015473NEI NIH HHS R01 EY030575NEI NIH HHS R01 EY032559
6 · The paper itself

Abstract

purposeInvestigate associations of race/ethnicity and preferred language with baseline glaucoma severity, VF test frequency and disease progression.

designRetrospective cohort study.

methodsPatients receiving VF testing at a tertiary eyecare center between 1998 and 2020 with self-identified race, ethnicity and preferred language were included. Outcome measures were VF MD and age at first visit, VF test frequency, VF MD progression.

resultsAmong 29,891 patients with VF measurements between 1998 and 2020, 55.1% were female, 71.0% self-identified as White/Caucasian, 14.0% as Black/African American, 7.4% as Asian and 6.4% as Hispanic, and 11.2% preferred a language other than English. Mean VF MD at presentation was worse among Black (-9.3±9.7 dB), Asian (-6.2±7.6 dB) and Hispanic (-8.3±9.3 dB) patients (vs. Whites [-5.5±7.3 dB, p<0.001] or non-Hispanics [-6.2±7.8 dB, p<0.001]). After controlling for age, gender and English proficiency, disparities in glaucoma severity at presentation were reduced, especially among Asian and Hispanic patients. Despite greater severity at presentation, Black patients had lower VF test frequency/person-years (1.07±0.53) compared to Whites (1.12±0.52, p=0.006) and worse VF MD progression (-0.43 dB/year, 95% CI -0.67 to -0.28, p<0.001). In contrast, Hispanics had a higher VF frequency vs. non-Hispanics (1.18±0.64 vs. 1.11±0.52, p<0.001), and no difference in VF progression (p=0.77).

conclusionsBlack, Asian and Hispanic patients had greater baseline severity vs. Whites. Unlike other groups, Black patients had a lower VF frequency vs. Whites and greater VF progression. Disparities in baseline severity were partially explained by English proficiency, especially for Asian and Hispanic patients.

Indexed as

GlaucomaVisual FieldsDisease ProgressionEthnicityFemaleHumansIntraocular PressureMaleRetrospective StudiesSeverity of Illness IndexVision DisordersVisual Field TestsGlaucomaglaucoma severityracial disparitiesvisual field mean deviationvisual field testing

Identifiers

PMID35654121
PMCPMC9842097
OpenAlexW4281755757

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.