Evidence map›Paper›PMID 35653889›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2022

Ipecac root extracts and isolated circular peptides differentially suppress inflammatory immune response characterised by proliferation, activation and degranulation capacity of human lymphocytes in vitro.

Chiara Madlen Falanga, Carmen Steinborn, Edin Muratspahić, Amy Marisa Zimmermann-Klemd, Moritz Winker, Liselotte Krenn, Roman Huber, Christian W Gruber, Carsten Gründemann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Chiara Madlen FalangaCenter for Complementary Medicine, Department of Internal Medicine II, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Carmen SteinbornCenter for Complementary Medicine, Department of Internal Medicine II, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Edin MuratspahićCenter for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Amy Marisa Zimmermann-KlemdTranslational Complementary Medicine, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Moritz WinkerTranslational Complementary Medicine, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Liselotte KrennDepartment of Pharmacognosy, University of Vienna, Vienna, Austria.
Roman HuberCenter for Complementary Medicine, Department of Internal Medicine II, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Christian W GruberCenter for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Carsten GründemannTranslational Complementary Medicine, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. Electronic address: carsten.gruendemann@unibas.ch.
University of Basel · CHUniversity of Freiburg · DEMedical University of Vienna · ATUniversity of Vienna · AT

Funding

Austrian Science Fund FWF P 32109
6 · The paper itself

Abstract

Circular peptides are attractive lead compounds for drug development; this study investigates the immunomodulatory effects of defined root powder extracts and isolated peptides (called cyclotides) from Carapichea ipecacuanha (Brot.) L. Andersson ('ipecac'). Changes in the viability, proliferation and function of activated human primary T cells were analysed using flow cytometry-based assays. Three distinct peptide-enriched extracts of pulverised ipecac root material were prepared via C

Indexed as

CyclotidesCell ProliferationHumansIpecacLymphocyte ActivationLymphocytesPeptides, CyclicCyclotidesIpecacPeptides, CyclicCarapichea ipecacuanhaCircular peptidesImmune modulationLymphocytes

Identifiers

PMID35653889
PMCPMC7614192
OpenAlexW4281836311

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.