Evidence map›Paper›PMID 35653820›Full record

ArticleJournal of inorganic biochemistry2022

Structural insights into the design of reversible fluorescent probes for metallo-β-lactamases NDM-1, VIM-2, and IMP-1.

Sky Price, Radhika Mehta, Dominique Tan, Abigail Hinojosa, Pei W Thomas, Tawanda Cummings, Walter Fast, Emily L Que

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sky PriceDepartment of Chemistry, University of Texas at Austin, 105 E 24(th) St Stop A5300, Austin, TX 78712, United States of America.
Radhika MehtaDepartment of Chemistry, University of Texas at Austin, 105 E 24(th) St Stop A5300, Austin, TX 78712, United States of America.
Dominique TanDepartment of Chemistry, University of Texas at Austin, 105 E 24(th) St Stop A5300, Austin, TX 78712, United States of America.
Abigail HinojosaDepartment of Chemistry, University of Texas at Austin, 105 E 24(th) St Stop A5300, Austin, TX 78712, United States of America.
Pei W ThomasDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy, and the LaMontagne Center for Infectious Disease, University of Texas at Austin, Austin, TX 78712, United States of America.
Tawanda CummingsDepartment of Chemistry, University of Texas at Austin, 105 E 24(th) St Stop A5300, Austin, TX 78712, United States of America.
Walter FastDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy, and the LaMontagne Center for Infectious Disease, University of Texas at Austin, Austin, TX 78712, United States of America.
Emily L QueDepartment of Chemistry, University of Texas at Austin, 105 E 24(th) St Stop A5300, Austin, TX 78712, United States of America. Electronic address: emilyque@cm.utexas.edu.

Funding

Targeted molecular strategies for cellular investigation of metalloproteinsR35GM133612 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI Emily L Que · 2019 to 2026
$2.8M
Developing Metallo-Beta-Lactamase InhibitorsR01GM111926 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BONOMO, ROBERT A., COHEN, SETH M · 2015 to 2019
$2.3M
NIGMS NIH HHS R01 GM111926NIGMS NIH HHS R35 GM133612
6 · The paper itself

Abstract

Metallo-β-lactamases (MBLs) are enzymes that are capable of hydrolyzing most β-lactam antibiotics and all clinically relevant carbapenems. We developed a library of reversible fluorescent turn-on probes that are designed to directly bind to the dizinc active site of these enzymes and can be used to study their dynamic metalation state and enzyme-inhibitor interactions. Structure-function relationships with regards to inhibitory strength and fluorescence turn-on response were evaluated for three representative MBLs.

Indexed as

beta-Lactamase InhibitorsFluorescent DyesAnti-Bacterial Agentsbeta-LactamasesAnti-Bacterial Agentsbeta-Lactamase Inhibitorsbeta-lactamase NDM-1beta-LactamasesFluorescent DyesAntibiotic resistanceFluorescent probeMetalloenzyme inhibitor

Identifiers

PMID35653820
PMCPMC9216179

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.