Evidence map›Paper›PMID 35653796›Full record

ArticleBioengineered2022

Decrease in Tripartite Motif Containing 24 suppresses hypoxia-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/mammalian target of rapamycin complex 1 pathway.

Jingwen Xu, Yujia Zhong, Zhang Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jingwen XuDepartment of Geriatrics, The General Hospital of Western Theater Command, Chengdu, P.R. China.
Yujia ZhongDepartment of Geriatrics, The General Hospital of Western Theater Command, Chengdu, P.R. China.
Zhang WangDepartment of Geriatrics, The General Hospital of Western Theater Command, Chengdu, P.R. China.ORCID 0000-0003-1951-7432

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tripartite Motif Containing 24 (TRIM24) is an oncogenic protein and promotes proliferation in several cancer cell lines. Nevertheless, the role of TRIM24 in proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) remains to be clarified. The current study was aimed to reveal the role of TRIM24 in proliferation and migration of PASMCs during the development of pulmonary arterial hypertension (PAH). In pulmonary arteries (PAs) of chronic hypoxia-PAH (CH-PAH) mice and PASMCs challenged with hypoxia, the expression of TRIM24 was increased. Silencing TRIM24 by

Indexed as

Hypertension, PulmonaryPulmonary Arterial HypertensionAnimalsCell ProliferationHypoxiaMammalsMechanistic Target of Rapamycin Complex 1MiceMyocytes, Smooth MuscleProto-Oncogene Proteins c-aktPulmonary ArteryTOR Serine-Threonine KinasesMechanistic Target of Rapamycin Complex 1Proto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAKTmTORC1pulmonary arterial hypertensionpulmonary artery smooth muscle cellsTRIM24

Identifiers

PMID35653796
PMCPMC9275953
OpenAlexW4281983008

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.