ArticleProceedings of the National Academy of Sciences of the United States of America2022
Gene-rich X chromosomes implicate intragenomic conflict in the evolution of bizarre genetic systems.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Genomic Insights into Basal Diptera Phylogeny: The Non-Monophyletic Nature of Blephariceromorpha.International journal of molecular sciences · 2025Article
- Faster adaptation but slower divergence of X chromosomes under paternal genome elimination.Nature communications · 2025Article
- Review
- Complete mitochondrial genome ofZooKeys · 2024Article
- Chromosome-Aware Phylogenomics of Assassin Bugs (Hemiptera: Reduvioidea) Elucidates Ancient Gene Conflict.Molecular biology and evolution · 2023Article
- Two New Mitogenomes of Bibionidae and Their Comparison within the Infraorder Bibionomorpha (Diptera).Genes · 2023Article
- Recent Evolution of a Maternally Acting Sex-Determining Supergene in a Fly with Single-Sex Broods.Molecular biology and evolution · 2023Article
- Genomic evidence of paternal genome elimination in the globular springtail Allacma fusca.Genetics · 2022Article
- Gene-rich germline-restricted chromosomes in black-winged fungus gnats evolved through hybridization.PLoS biology · 2022Article
- Evolutionary Perspectives on Germline-Restricted Chromosomes in Flies (Diptera).Genome biology and evolution · 2021Review
- Males That Silence Their Father's Genes: Genomic Imprinting of a Complete Haploid Genome.Molecular biology and evolution · 2021Article
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9 authors.
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Abstract
Haplodiploidy and paternal genome elimination (HD/PGE) are common in invertebrates, having evolved at least two dozen times, all from male heterogamety (i.e., systems with X chromosomes). However, why X chromosomes are important for the evolution of HD/PGE remains debated. The Haploid Viability Hypothesis posits that X-linked genes promote the evolution of male haploidy by facilitating purging recessive deleterious mutations. The Intragenomic Conflict Hypothesis holds that conflict between genes drives genetic system turnover; under this model, X-linked genes could promote the evolution of male haploidy due to conflicts with autosomes over sex ratios and genetic transmission. We studied lineages where we can distinguish these hypotheses: species with germline PGE that retain an XX/X0 sex determination system (gPGE+X). Because evolving PGE in these cases involves changes in transmission without increases in male hemizygosity, a high degree of X linkage in these systems is predicted by the Intragenomic Conflict Hypothesis but not the Haploid Viability Hypothesis. To quantify the degree of X linkage, we sequenced and compared 7 gPGE+X species’ genomes with 11 related species with typical XX/XY or XX/X0 genetic systems, representing three transitions to gPGE. We find highly increased X linkage in both modern and ancestral genomes of gPGE+X species compared to non-gPGE relatives and recover a significant positive correlation between percent X linkage and the evolution of gPGE. These empirical results substantiate longstanding proposals for a role for intragenomic conflict in the evolution of genetic systems such as HD/PGE.
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