Evidence map›Paper›PMID 35653554›Full record

Trial reportBasic & clinical pharmacology & toxicology2022

Comparison of ciprofol (HSK3486) versus propofol for the induction of deep sedation during gastroscopy and colonoscopy procedures: A multi-centre, non-inferiority, randomized, controlled phase 3 clinical trial.

Junxiang Li, Xiao Wang, Jin Liu, Xia Wang, Xiangkui Li, Yaping Wang, Wen Ouyang, Jun Li, Shanglong Yao, Zhaoqiong Zhu and 4 more

2 registry-linked trialsOpen access · hybridAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Basic & clinical pharmacology & toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 109 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 14 pooled it
44.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07028593 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery (CP-MINS) in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Randomized, Double-Blind, Propofol-Controlled, Multicenter Trial

TypeinterventionalSponsorTongji HospitalRan2025 to 2027Enrolled1,058ConditionsMyocardial Injury, Thoracic Diseases, Thoracoscopic SurgeryArmsPropofol, ciprofol
NCT07294989 recruitingnot on this mapstarted 2025, after this paper: background citation

Median Effective Concentration of Ciprofol and Its Correlation With Bispectral Index: A Prospective Observational Study

Typeobservational_patient_registrySponsorPeking University Shenzhen HospitalRan2025 to 2026Enrolled101ConditionsThyroid DiseaseArmsCiprofol
3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 14 syntheses or guidelines pooled it, 190 citations in OpenAlex.

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  16. Comparison of Ciprofol-Nalbuphine and Propofol-Nalbuphine Sedation During Painless Gastrointestinal Endoscopy: A Randomized Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2026
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Junxiang LiDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Xiao WangDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-1628-9158
Jin LiuDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Xia WangDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Xiangkui LiDepartment of Anesthesiology, Sichuan Provincial People's Hospital, Chengdu, China.
Yaping WangDepartment of Anesthesiology, The Second Xiangya Hospital of Central South University, Changsha, China.
Wen OuyangDepartment of Anesthesiology, The Third Xiangya Hospital of Central South University, Changsha, China.
Jun LiDepartment of Anesthesiology, The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0002-6700-5901
Shanglong YaoDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhaoqiong ZhuDepartment of Anesthesiology, Affiliated Hospital of Zunyi Medical College, Zunyi, China.
Qulian GuoDepartment of Anesthesiology, Xiangya Hospital, Central South University, Changsha, China.
Yonghao YuDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China.
Jinhai MengDepartment of Anesthesiology, General Hospital of Ningxia Medical University, Yinchuan, China.
Yunxia ZuoDepartment of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-3539-5706
Sichuan University · CNCentral South University · CNAffiliated Hospital of Zunyi Medical College · CNFourth People's Hospital of Sichuan Province · CNNingxia Medical University · CNTianjin Medical University General Hospital · CNUnion Hospital · CN

Funding

Haisco Pharmaceutical Group Co., Ltd
6 · The paper itself

Abstract

Ciprofol is a propofol analogue with improved pharmacokinetic properties. A multi-centre, non-inferiority trial was conducted to compare the deep sedation properties of ciprofol and propofol with a non-inferiority margin of 8% in patients undergoing gastroscopy and colonoscopy. In total, 289 patients were randomly allocated for surgery (259 colonoscopy and 30 gastroscopy) at a 1:1 ratio to be given intravenous injections of ciprofol (0.4 mg/kg) or propofol (1.5 mg/kg). The primary outcome was the success rate of colonoscopy defined as colonoscopy completion with no need for an alternative sedative or >5 ciprofol or propofol top up doses within any 15-min time period. The success rate of colonoscopy was 100% in the ciprofol group vs. 99.2% in the propofol group (mean difference 0.8%, 95% CI: -2.2% to 4.2%). Except for the gastrointestinal lesions found during the gastroscopy and colonoscopy procedures, the occurrence rates of adverse drug reactions in the ciprofol and propofol groups were 31.3% and 62.8%, respectively (P < 0.001). Pain on injection was less common in the ciprofol group (4.9% vs. 52.4%, P < 0.001). The outcomes demonstrated that ciprofol was non-inferior to propofol with regard to successful sedation for gastroscopy or colonoscopy procedures and no obvious important adverse events occurred.

Indexed as

Deep SedationPropofolColonoscopyGastroscopyHumansHypnotics and SedativesHypnotics and SedativesPropofolciprofolcolonoscopydeep sedationgastroscopypropofol

Identifiers

PMID35653554
PMCPMC9543620
OpenAlexW4281707865

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.