ReviewBrain : a journal of neurology2022
A new science of emotion: implications for functional neurological disorder.
Review in Brain : a journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- Pain and functional neurological disorder: a systematic review and meta-analysis.Journal of neurology, neurosurgery, and psychiatry · 2024Pooled it
- Mechanistic studies in pathological health anxiety: A systematic review and emerging conceptual framework.Journal of affective disorders · 2024Pooled it
- Randomised feasibility study evaluating eye movement desensitisation and reprocessing therapy for functional neurological disorder (MODIFI).Journal of neurology · 2025Trial
- The sixth sense of the brain: interoception in organoid study.Bone research · 2026Review
- Somatic yoga therapy for functional neurological disorder: feasibility randomised controlled trial.BJPsych open · 2026Article
- Functional Connectivity Gradients Reveal Altered Hierarchical Cortical Organization in Functional Neurological Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Difference in clinical characteristics between functional syncope and vasovagal syncope in children.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- How Were Functional Somatic Symptoms in Children Influenced by the COVID-19 Pandemic? A Retrospective Study of Children Admitted to a Tertiary Pediatric Emergency Hospital in Bucharest, Romania.Life (Basel, Switzerland) · 2026Article
- Sleep in Functional Motor Disorders: A Case-Control Polysomnographic Study.Journal of sleep research · 2026Article
- Cognition and metacognition in functional motor symptoms and functional seizures: a case-control study.Psychological medicine · 2026Article
- Exploring the autism and functional neurological disorder association: Considerations from biopsychosocial, neuropsychological and computational models.Autism : the international journal of research and practice · 2026Review
- Functional Connectivity Predictors and Mechanisms of Symptom Change in Functional Neurological Disorder.medRxiv : the preprint server for health sciences · 2026Article
- Epigenetic Dysregulation in Neurodegeneration: The Role of Histone Deacetylases and Emerging Inhibitor Strategies.Biomolecules · 2026Review
- Relationships between brain functional connectivity and resting cardiac autonomic profiles in functional neurological disorder: A pilot study.NeuroImage. Clinical · 2026Article
- Functional sensory symptoms and signs: a case-control study of 102 patients.Brain communications · 2026Article
- Functional connectivity predictors and mechanisms of symptom change in functional neurological disorder.Brain communications · 2026Article
- Ultra-high field brain MRI for functional neurological disorder: opportunities and challenges.NeuroImage. Clinical · 2026Review
- Attenuated heartbeat-evoked potentials in functional neurological disorder.Brain communications · 2026Article
- Relearning the epistemology, history, and future of neuropsychiatry.Frontiers in human neuroscience · 2026Review
- Uncertainty as an operative construct and treatment target in functional neurological disorder.Frontiers in psychiatry · 2026Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Functional neurological disorder reflects impairments in brain networks leading to distressing motor, sensory and/or cognitive symptoms that demonstrate positive clinical signs on examination incongruent with other conditions. A central issue in historical and contemporary formulations of functional neurological disorder has been the mechanistic and aetiological role of emotions. However, the debate has mostly omitted fundamental questions about the nature of emotions in the first place. In this perspective article, we first outline a set of relevant working principles of the brain (e.g. allostasis, predictive processing, interoception and affect), followed by a focused review of the theory of constructed emotion to introduce a new understanding of what emotions are. Building on this theoretical framework, we formulate how altered emotion category construction can be an integral component of the pathophysiology of functional neurological disorder and related functional somatic symptoms. In doing so, we address several themes for the functional neurological disorder field including: (i) how energy regulation and the process of emotion category construction relate to symptom generation, including revisiting alexithymia, 'panic attack without panic', dissociation, insecure attachment and the influential role of life experiences; (ii) re-interpret select neurobiological research findings in functional neurological disorder cohorts through the lens of the theory of constructed emotion to illustrate its potential mechanistic relevance; and (iii) discuss therapeutic implications. While we continue to support that functional neurological disorder is mechanistically and aetiologically heterogenous, consideration of how the theory of constructed emotion relates to the generation and maintenance of functional neurological and functional somatic symptoms offers an integrated viewpoint that cuts across neurology, psychiatry, psychology and cognitive-affective neuroscience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.