SynthesisPloS one2022
The risk of preterm birth in women with uterine fibroids: A systematic review and meta-analysis.
Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- The Annual Economic Burden of Uterine Fibroids in the United States (2010 Versus 2022): A Comparative Cost-Analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2024Pooled it
- A systematic review of risk factors associated with depression and anxiety in cancer patients.PloS one · 2024Pooled it
- Leiomyomata, neonatal anthropometry, and pregnancy outcomes in singleton pregnancies.Annals of epidemiology · 2023Trial
- Machine-Learning-Based Prediction of Preterm Birth in Women with Huge Uterine Fibroids: A Stratified Cohort Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- Uterine fibroids detected in early pregnancy and their association with adverse pregnancy outcomes: a single-centre retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Blood-based biomarkers and delirium in critically ill adults in the ICU: a systematic review.Intensive care medicine experimental · 2026Review
- Association of uterine fibroids with adverse pregnancy outcomes: a retrospective cohort study.BMC pregnancy and childbirth · 2026Article
- Hypertension identified in early adulthood as an endocrine-vascular risk factor for uterine fibroids in reproductive-age women: a nationwide cohort study.Frontiers in endocrinology · 2026Article
- A prognostic nomogram for assessing the risk of recurrence after laparoscopic myomectomy.Journal of assisted reproduction and genetics · 2025Article
- Perinatal Outcomes in Mexican Women with a History of Myomectomy: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Influence of uterine fibroid size on perinatal and neonatal outcomes: a single-centre cohort of 651 pregnancies.BMC pediatrics · 2025Article
- Biomarkers in Pediatric Neuropsychiatric Systemic Lupus Erythematosus: A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Thyroid Cancer in Childhood Leukemia Survivors: A Systematic Review of the Incidence and Survival Outcomes.Journal of clinical medicine · 2025Review
- Effects of polydimethylsiloxane membrane surface treatments on human uterine smooth muscle cell strain response.Bioactive materials · 2024Article
- Selecting the best surgical approach in various cases of prolapsed pedunculated submucosal fibroids: A case series.International journal of surgery case reports · 2023Article
- In-bag extraction of tissue through an incision in the posterior vaginal wall in laparoscopic myomectomy: a large retrospective study.BMC women's health · 2023Article
- Fertility-enhancing hysteroscopic surgery; multi-center retrospective cohort study of reproductive outcome.BMC women's health · 2023Article
- Challenges and Opportunities for Data Science in Women's Health.Annual review of biomedical data science · 2023Review
- Regulation of oxytocin-induced calcium transients and gene expression in engineered myometrial tissues by tissue architecture and matrix rigidity.Current research in physiology · 2023Article
- Uterine Fibroids Causing Preterm Birth: A New Pathophysiological Hypothesis on the Role of Fibroid Necrosis and Inflammation.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFibroids have been identified as a possible risk factor for preterm birth, however, the magnitude of this risk is unclear. Our objective was to determine the risk of total, spontaneous, and medically indicated preterm birth in women with fibroids.
methodsA literature search was performed on 9 June 2021. We selected studies reporting on preterm birth in women with and without fibroids. Fibroids had to be diagnosed by routine ultrasound before or during pregnancy. Main outcomes were total preterm birth <37, <34, <32, and <28 weeks of gestation, and spontaneous and medically indicated preterm birth. Two authors independently performed study selection, data extraction and quality assessment. We performed quality assessment with the Newcastle-Ottawa scale. Meta-analyses were presented as Odds Ratios (ORs) with 95% Confidence Intervals (95%CIs). MAIN
resultsThe search yielded 2078 unique articles of which 11 were included. Meta-analysis for preterm birth <37 weeks of gestation included 256,650 singleton deliveries: 12,309 with fibroids and 244,341 without fibroids. Women with fibroids had a higher rate of preterm birth (11.6% versus 9.0%; OR 1.66, 95%CI 1.29-2.14). Fibroids were also associated with preterm birth <34 (OR 1.88, 95%CI 1.34-2.65), <32 (OR 2.03, 95%CI 1.40-2.95) and <28 (OR 2.24, 95%CI 1.45-3.47) weeks of gestation. Data on type of preterm birth was limited: one study showed a significant association of fibroids with spontaneous preterm birth and another with indicated preterm birth. The main limitations of the included studies were the lack of correction for confounders, the risk of ascertainment bias due to possible underreporting of fibroids, and the substantial heterogeneity between studies.
conclusionsOur results suggest fibroids are associated with an increased risk of preterm birth, with a stronger risk at earlier gestational ages. We encourage further research to clarify the association between fibroids and preterm birth by systematic myometrial assessment in pregnancy. REGISTRATION: Prospero database [CRD42020186976].
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