ArticlePLoS computational biology2022
Radical pairs may explain reactive oxygen species-mediated effects of hypomagnetic field on neurogenesis.
Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Mitochondria as key targets underlying hypomagnetic field-induced biological effects.iScience · 2026Review
- Quantum Effects in Evolution: Terrestrial Fine-Tuning of Magnetic Parameters.Computational and structural biotechnology journal · 2026Article
- Article
- Magnetoreceptive CRY/MagR complexes: linking circadian redox signalling to protein aggregation in Alzheimer's and Parkinson's disease.ADMET & DMPK · 2026Review
- Quantum medicine: A quantum-mechanical framework for redox biology, disease and precision medicine.Clinical and translational medicine · 2026Review
- Weak Radiofrequency Field Effects on Biological Systems Mediated through the Radical Pair Mechanism.Chemical reviews · 2025Review
- Magneto-oncology: a radical pair primer.Frontiers in oncology · 2025Review
- Magnetosensitivity of tightly bound radical pairs in cryptochrome is enabled by the quantum Zeno effect.Nature communications · 2024Article
- Quantum theory of a potential biological magnetic field sensor: Radical pair mechanism in flavin adenine dinucleotide biradicals.Computational and structural biotechnology journal · 2024Article
- Avian cryptochrome 4 binds superoxide.Computational and structural biotechnology journal · 2024Article
- Verification of radical pair mechanism predictions for weak magnetic field effects on superoxide in planarians.bioRxiv : the preprint server for biology · 2024Article
- Review
- Radical pair model for magnetic field effects on NMDA receptor activity.Scientific reports · 2024Article
- Article
- 'Seeing' the electromagnetic spectrum: spotlight on the cryptochrome photocycle.Frontiers in plant science · 2024Review
- Magnetic Field Intervention Enhances Cellular Migration Rates in Biological Scaffolds.Bioengineering (Basel, Switzerland) · 2023Article
- Magnetic isotope effects: a potential testing ground for quantum biology.Frontiers in physiology · 2023Article
- Radical triads, not pairs, may explain effects of hypomagnetic fields on neurogenesis.PLoS computational biology · 2022Article
- Magnetic field effects in biology from the perspective of the radical pair mechanism.Journal of the Royal Society, Interface · 2022Review
- Radical pairs may explain reactive oxygen species-mediated effects of hypomagnetic field on neurogenesis.PLoS computational biology · 2022Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Exposures to a hypomagnetic field can affect biological processes. Recently, it has been observed that hypomagnetic field exposure can adversely affect adult hippocampal neurogenesis and hippocampus-dependent cognition in mice. In the same study, the role of reactive oxygen species (ROS) in hypomagnetic field effects has been demonstrated. However, the mechanistic reasons behind this effect are not clear. This study proposes a radical pair mechanism based on a flavin-superoxide radical pair to explain the modulation of ROS production and the attenuation of adult hippocampal neurogenesis in a hypomagnetic field. The results of our calculations favor a singlet-born radical pair over a triplet-born radical pair. Our model predicts hypomagnetic field effects on the triplet/singlet yield of comparable strength as the effects observed in experimental studies on adult hippocampal neurogenesis. Our predictions are in qualitative agreement with experimental results on superoxide concentration and other observed ROS effects. We also predict the effects of applied magnetic fields and oxygen isotopic substitution on adult hippocampal neurogenesis.
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