ArticleInvestigative ophthalmology & visual science2022
The Ganglion Cell-Inner Plexiform Layer Thickness/Vessel Density of Superficial Vascular Plexus Ratio According to the Progression of Diabetic Retinopathy.
Article in Investigative ophthalmology & visual science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Explicit Inclusion of Diabetes Mellitus Without Retinopathy Within Diabetic Retinopathy Prediction.Translational vision science & technology · 2026Article
- Molecular stress and neurovascular injury in the diabetic retina.The Journal of clinical investigation · 2026Review
- The Effect of Periodontitis Severity on Diabetic Retinopathy: An Optical Coherence Tomography Study.Diagnostics (Basel, Switzerland) · 2026Article
- The Association of Retinal Capillary Density and Retinal Thickness in Diabetic Retinopathy.Investigative ophthalmology & visual science · 2025Article
- Article
- Early retinal changes in type 2 diabetes detected by texture-based OCT analysis: potential approach for subclinical diabetic retinopathy diagnosis.Eye and vision (London, England) · 2025Article
- Effect of calcium dobesilate on macular microvasculature in patients with diabetic retinopathy.PloS one · 2025Article
- Associations of retinal neurovascular dysfunction with inner retinal layer thickness in non-proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Retinal neurodegeneration in diabetic retinopathy with systemic hypertension.Acta diabetologica · 2024Article
- Patterns of Structural Changes in the Fundus Measured by Optical Coherence Tomography Angiography as Potential Markers of Acute Mountain Sickness.Translational vision science & technology · 2023Article
- Changes in peripapillary microvasculature in patients with type 2 diabetes patients: effect of systemic hypertension.Scientific reports · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to identify the relationship between the gangion cell-inner plexiform layer (GC-IPL) and retinal vasculature in the context of the progression of diabetic retinopathy (DR). Methods: The subjects were divided into four groups according to DR stage: normal controls (group 1), patients with diabetes mellitus (DM) without DR (group 2), patients with mild or moderate nonprogressive DR (NPDR; group 3), and patients with severe NPDR (group 4). GC-IPL thickness, vessel density of superficial vascular plexus (SVD), and the GC-IPL/SVD ratio were compared among the groups. Results: A total of 556 eyes were enrolled; 288 in group 1, 140 in group 2, 76 in group 3, and 52 in group 4. The mean GC-IPL thicknesses were 83.57 ± 7.35, 82.74 ± 7.22, 81.33 ± 6.74, and 79.89 ± 9.16 μm in each group, respectively (P = 0.006). The mean SVDs were 20.40 ± 1.26, 19.70 ± 1.56, 18.86 ± 2.04, and 17.82 ± 2.04 mm-1 in each group, respectively (P < 0.001). The GC-IPL/SVD ratios were 4.11 ± 0.38, 4.22 ± 0.40, 4.36 ± 0.54, and 4.54 ± 0.55 in each group, respectively (P < 0.001). In Pearson's correlation analysis, DR stage was significantly correlated with the GC-IPL/SVD ratio (coefficient = 0.301; P < 0.001). Conclusions: As the DR stage progressed, the GC-IPL thickness tended to decrease, with the macular SVD showing a significant reduction. Additionally, the impairment of retinal vasculature was more prominent than GC-IPL thinning as DR progressed, which suggests that retinal vasculature changes may precede diabetic retinal neurodegeneration.
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