Evidence map›Paper›PMID 35653032›Full record

ArticleBiological trace element research2023

Effects of Sodium Chromate Exposure on Gene Expression Profiles of Primary Rat Hepatocytes (In Vitro).

Xiaofeng Li, Abdel-Moneim Eid Abdel-Moneim, Jinling Hua, Lei Zhao, Zhongze Hu, Xunsheng Pang, Shujuan Wang, Zhihao Chen, Bing Yang

Abstract read
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In one paragraph

Article in Biological trace element research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Xiaofeng LiAnhui Key Laboratory of Poultry Infectious Disease Prevention and Control, College of Animal Science, Anhui Science and Technology University, Fengyang, 233100, China.
Abdel-Moneim Eid Abdel-MoneimBiological Applications Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Abu-Zaabal, 13759, Egypt.
Jinling HuaAnhui Key Laboratory of Poultry Infectious Disease Prevention and Control, College of Animal Science, Anhui Science and Technology University, Fengyang, 233100, China.
Lei ZhaoAnhui Key Laboratory of Poultry Infectious Disease Prevention and Control, College of Animal Science, Anhui Science and Technology University, Fengyang, 233100, China.
Zhongze HuAnhui Key Laboratory of Poultry Infectious Disease Prevention and Control, College of Animal Science, Anhui Science and Technology University, Fengyang, 233100, China.
Xunsheng PangAnhui Key Laboratory of Poultry Infectious Disease Prevention and Control, College of Animal Science, Anhui Science and Technology University, Fengyang, 233100, China.
Shujuan WangAnhui Key Laboratory of Poultry Infectious Disease Prevention and Control, College of Animal Science, Anhui Science and Technology University, Fengyang, 233100, China.
Zhihao ChenAnhui Key Laboratory of Poultry Infectious Disease Prevention and Control, College of Animal Science, Anhui Science and Technology University, Fengyang, 233100, China.
Bing YangAnhui Key Laboratory of Poultry Infectious Disease Prevention and Control, College of Animal Science, Anhui Science and Technology University, Fengyang, 233100, China. bingyang19860919@163.com.ORCID http://orcid.org/0000-0002-7657-2158
Anhui University of Science and Technology · CNEgyptian Atomic Energy Authority · EG

Funding

the Talent Introduction Program of Anhui Science and Technology University DKYJ202003
6 · The paper itself

Abstract

Chromium exposure has adverse impacts on human health and the environment, whereas chromate-induced hepatotoxicity's detailed mechanism is still unclear. Therefore, the purpose of the current study was to reveal the crucial signaling pathways and genes linked to sodium chromate-induced hepatotoxicity. GSE19662, a gene expression microarray, was obtained from Gene Expression Omnibus (GEO). Six primary rat hepatocyte (PRH) samples from GSE19662 include sodium chromate-treated (n = 3) and the control PRH samples (n = 3). A total of 2,525 differentially expressed genes (DEGs) were obtained, especially 962, and 1,563 genes were up- and downregulated in sodium chromate-treated PRHs compared to the control. Gene ontology (GO) enrichment analysis suggested that those DEGs were involved in multiple biological processes, including the response to toxic substances, the positive regulation of apoptotic process, lipid and cholesterol metabolic process, and others. Signaling pathway enrichment analysis indicated that the DEGs were mainly enriched in MAPK, PI3K-Akt, PPAR, AMPK, cellular senescence, hepatitis B, fatty acid biosynthesis, etc. Moreover, many genes, including CYP2E1, CYP1A2, CYP2C13, CDK1, NDC80, and CCNB1, might contribute to sodium chromate-induced hepatotoxicity. Taken together, this study enhances our knowledge of the potential molecular mechanisms of sodium chromate-induced hepatotoxicity.

Indexed as

Chemical and Drug Induced Liver InjuryTranscriptomeAnimalsChromatesComputational BiologyGene Expression ProfilingGene Expression Regulation, NeoplasticHepatocytesHumansPhosphatidylinositol 3-KinasesRatsSodium CompoundsChromatesPhosphatidylinositol 3-Kinasessodium chromate(VI)Sodium CompoundsGeneHepatotoxicitySignaling pathwaySodium chromate

Identifiers

PMID35653032
OpenAlexW4281965470

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.