Evidence map›Paper›PMID 35652975›Full record

ArticleMolecular diversity2023

Synthesis of fused polycyclic β-carboline derivatives using Ugi-4CR followed by cascade cyclization.

Vipin Kumar, Anjali Saxena, Ranjan Patra, Devalina Ray, Hong-Yu Li, Biswajit Saha

Abstract read
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In one paragraph

Article in Molecular diversity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Recent Advances in the Green Synthesis of ActivePharmaceuticals (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vipin KumarAmity Institute of Click Chemistry Research and Studies, Amity University, Sector 125, Noida, Uttar Pradesh, 201313, India.
Anjali SaxenaAmity Institute of Biotechnology, Amity University, Sector 125, Noida, Uttar Pradesh, 201313, India.
Ranjan PatraAmity Institute of Click Chemistry Research and Studies, Amity University, Sector 125, Noida, Uttar Pradesh, 201313, India.
Devalina RayAmity Institute of Click Chemistry Research and Studies, Amity University, Sector 125, Noida, Uttar Pradesh, 201313, India.
Hong-Yu LiDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Biswajit SahaAmity Institute of Biotechnology, Amity University, Sector 125, Noida, Uttar Pradesh, 201313, India. bsaha1@amity.edu.ORCID http://orcid.org/0000-0003-3414-5059

Funding

Alexander von Humboldt-Stiftung fellowshipScience and Engineering Research Board CRG/2019/002333Science and Engineering Research Board CS-192/2011
6 · The paper itself

Abstract

Ugi-four component reaction (Ugi-4CR) is extremely attractive for diversity-oriented and step economical synthesis as evident from past applications. Here we report the synthesis of fused polycyclic β-carboline derivatives by sequential Pictet-Spengler's and Ugi-4CR multi-component reaction followed by cascade cyclization. The post cyclisation of Ugi product provides conformationally stable heterocyclic molecule that is expected to be suitable for interaction with different biological targets. The methodology provides a simple and facile access to heterocycles embedded in polycyclic framework which otherwise seems difficult to synthesize by conventional methods. Synthesis of fused Polycyclic β-Carboline Derivatives Using Ugi-4CR Followed by Cascade Cyclization.

Indexed as

CarbolinesCyclizationCarbolinesCascade cyclizationPolycyclic β-carboline derivativesUgi-4CR

Identifiers

PMID35652975

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.