Evidence map›Paper›PMID 35652974›Full record

ArticleCellular and molecular life sciences : CMLS2022

Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.

Alexandra Ralevski, Federico Apelt, Justyna J Olas, Bernd Mueller-Roeber, Elena I Rugarli, Friedrich Kragler, Tamas L Horvath

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Alexandra RalevskiDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.
Federico ApeltMax Planck Institute of Molecular Plant Physiology, Wissenschaftspark Golm, 14476, Potsdam, Germany.
Justyna J OlasDepartment of Molecular Biology, University of Potsdam, Karl-Liebknecht-Strasse 24-25, 14476, Potsdam, Germany.
Bernd Mueller-RoeberMax Planck Institute of Molecular Plant Physiology, Wissenschaftspark Golm, 14476, Potsdam, Germany.
Elena I RugarliDepartment of Biology, Institute for Genetics, University of Cologne, Cologne, Germany.
Friedrich KraglerMax Planck Institute of Molecular Plant Physiology, Wissenschaftspark Golm, 14476, Potsdam, Germany.
Tamas L HorvathDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA. tamas.horvath@yale.edu.ORCID http://orcid.org/0000-0002-7522-4602
Max Planck Institute of Molecular Plant Physiology · DEUniversity of Potsdam · DEYale Cancer Center · USUniversity of Cologne · DE

Funding

The role of AgRP/Auga-ALK pathway in FGF21's brain action on agingP01AG051459 · NIA · YALE UNIVERSITY · PI VISHWA DEEP DIXIT · 2016 to 2026
$25.7M
PET imaging of AD-related markers in non-human primatesR01AG052986 · NIA · YALE UNIVERSITY · PI HORVATH, TAMAS L, LAWRENCE, MATTHEW SWAN · 2017 to 2020
$2.9M
AgRP neurons promote the effects of calorie restriction on lifespanR01AG052005 · NIA · YALE UNIVERSITY · PI HORVATH, TAMAS L · 2017 to 2021
$2.2M
Feeding Driven by POMC NeuronsR01DK111178 · NIDDK · YALE UNIVERSITY · PI HORVATH, TAMAS L · 2017 to 2020
$1.9M
In vivo and in vitro systems to validate geronic proteins and their mechanisms of actionR56AG052986 · NIA · YALE UNIVERSITY · PI HORVATH, TAMAS L, LAWRENCE, MATTHEW SWAN · 2016 to 2016
$494k
NIA NIH HHS P01 AG051459NIA NIH HHS R01 AG052005NIA NIH HHS R01 AG052986NIA NIH HHS R56 AG052986NIDDK NIH HHS R01 DK111178
6 · The paper itself

Abstract

Mitochondria in animals are associated with development, as well as physiological and pathological behaviors. Several conserved mitochondrial genes exist between plants and higher eukaryotes. Yet, the similarities in mitochondrial function between plant and animal species is poorly understood. Here, we show that FMT (FRIENDLY MITOCHONDRIA) from Arabidopsis thaliana, a highly conserved homolog of the mammalian CLUH (CLUSTERED MITOCHONDRIA) gene family encoding mitochondrial proteins associated with developmental alterations and adult physiological and pathological behaviors, affects whole plant morphology and development under both stressed and normal growth conditions. FMT was found to regulate mitochondrial morphology and dynamics, germination, and flowering time. It also affects leaf expansion growth, salt stress responses and hyponastic behavior, including changes in speed of hyponastic movements. Strikingly, Cluh

Indexed as

ArabidopsisArabidopsis ProteinsAnimalsLocomotionMammalsMiceMitochondriaMitochondrial ProteinsArabidopsis ProteinsMitochondrial ProteinsArabidopsis thalianaCLUHFMTHyponastyLocomotionMiceMitochondria

Identifiers

PMID35652974
PMCPMC11071973
OpenAlexW4281679192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.