Evidence map›Paper›PMID 35652973›Full record

ArticleJournal of computer-aided molecular design2022

Deciphering the conformational transitions of LIMK2 active and inactive states to ponder specific druggable states through microsecond scale molecular dynamics simulation.

Hemavathy Nagarajan, Ansar Samdani, Vetrivel Umashankar, Jeyaraman Jeyakanthan

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of computer-aided molecular design, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hemavathy NagarajanStructural Biology and Bio-Computing Lab, Department of Bioinformatics, Alagappa University, Science Block, Karaikudi, Tamil Nadu, 630003, India.
Ansar SamdaniCentre for Bioinformatics, Kamalnayan Bajaj Institute for Research in Vision and Ophthalmology, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, 600006, India.
Vetrivel UmashankarDepartment of Bioinformatics, ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, 590010, India.
Jeyaraman JeyakanthanStructural Biology and Bio-Computing Lab, Department of Bioinformatics, Alagappa University, Science Block, Karaikudi, Tamil Nadu, 630003, India. jjeyakanthan@alagappauniversity.ac.in.
Alagappa University · INInstitute of Bioinformatics · INSankara Nethralaya · IN

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/PR40154/BTIS/137/34/2021Department of Science and Technology, Ministry of Science and Technology, India /2019/IF190083Department of Science and Technology, Ministry of Science and Technology, India SR/FST/LSI-667/2016
6 · The paper itself

Abstract

LIMK2 inhibitors are one of the potential therapeutic modalities for treating various diseases. In the current scenario, there is a paucity of effective LIMK inhibitors that are highly specific with minimal off-target effects. To date, the conformational transitions of LIMK2 from DFG

Indexed as

Molecular Dynamics SimulationAllosteric SiteBinding SitesMolecular ConformationProtein ConformationActivation loopActiveDFGInactiveLIMK2MicrosecondMolecular dynamics simulation

Identifiers

PMID35652973
OpenAlexW4281649287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.