Evidence map›Paper›PMID 35652886›Full record

ArticleAnnals of medicine2022

The causal relationships between obstructive sleep apnea and elevated CRP and TNF-α protein levels.

Minhan Yi, Wangcheng Zhao, Yun Tan, Quanming Fei, Kun Liu, Ziliang Chen, Yuan Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Minhan YiDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.
Wangcheng ZhaoDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.
Yun TanDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.
Quanming FeiDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.
Kun LiuSchool of Life Sciences, Central South University, Changsha, China.
Ziliang ChenSchool of Computer Science and Engineering, Central South University, Changsha, China.
Yuan ZhangDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-0577-7129
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObstructive sleep apnea (OSA) and inflammation are closely related. This study aimed to evaluate the associations and causal effect between C-reactive protein (CRP) and tumour necrosis factor-alpha (TNF-α) levels andOSA.

methodsPooled analysis was conducted to compare the expression differences of CRP and TNF-α between OSA patients with different severity and controls, and between continuous positive airway pressure (CPAP) and non-CPAP interventions for OSA patients. Using published GWAS summary statistics, we conducted a bidirectional two-sample Mendelian Randomization (MR) to estimate the causal relationships between CRP and TNF-α levels and OSA risk. Effect estimates were evaluated using inverse-variance weighted (IVW) as primary method, and several other MR methods as sensitivity analysis.

resultsBoth TNF-α (WMD [95%CI] = 5.86 [4.80-6.93] pg/ml,

conclusionsIncreased CRP and TNF-α were associated with OSA severity and sensible to CPAP treatment. Also, OSA had a suggestive causal effect on elevated CRP.

Indexed as

Sleep Apnea, ObstructiveTumor Necrosis Factor-alphaContinuous Positive Airway PressureC-Reactive ProteinHumansInflammationC-Reactive ProteinTumor Necrosis Factor-alphaCPAPCRPMendelian RandomizationObstructive sleep apneaTNF-α

Identifiers

PMID35652886
PMCPMC9176672
OpenAlexW4281692048

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.