ArticleJournal of diabetes science and technology2023
Effect of Diabetes on Tendon Structure and Function: Not Limited to Collagen Crosslinking.
Article in Journal of diabetes science and technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 29 citations in OpenAlex.
- Plantar fascia thickness in type 1 diabetes mellitus patients: Clinical associations and metabolic correlates.Journal of diabetes investigation · 2026Article
- Serum Advanced Glycation End Products as Drivers of Poor Tendon Outcomes in Diabetes? An Emerging Hypothesis and Narrative Review.Endocrinology, diabetes & metabolism · 2026Review
- Excision without Reconstruction of a Traumatically Ruptured Extensor Indicis Proprius Tendon in a Diabetic Patient: A Case Report.Journal of orthopaedic case reports · 2026Article
- Achilles tenocytes from diabetic and non diabetic donors exposed to hyperglycemia respond differentially to inflammatory stimuli and stretch.Journal of anatomy · 2026Article
- Asymptomatic Rotator Cuff Tendinopathy in Elderly Diabetics: Is Routine Magnetic Resonance Imaging Evaluation of the Shoulder Warranted?Malaysian orthopaedic journal · 2026Article
- ROS-responsive Ganoderma lucidum polysaccharide nanocomposite targeting prosenescent oxidative stress niche for structural and functional diabetic tendon regeneration.Journal of nanobiotechnology · 2026Article
- An overview in tendon's physiology, pathomorphology, and treatment options.Cell and tissue research · 2026Review
- Recent advances in tendon redox biology: the interplay of oxidative stress, calcium signaling, and antioxidant defence mechanisms.Frontiers in pharmacology · 2026Review
- Current Perspectives on Protein Supplementation in Athletes: General Guidance and Special Considerations for Diabetes-A Narrative Review.Nutrients · 2025Review
- Metabolic-associated enthesitis: a review on pathophysiology, clinical relevance, diagnostic challenges, and perspective on target treatments.Immunologic research · 2025Review
- Shear wave elastography of the supraspinatus tendon with early degeneration in asymptomatic type II diabetes mellitus patients: a multicenter study.BMC musculoskeletal disorders · 2025Article
- Relationship Between Structure and Age in Healthy Achilles Tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- The interplay between metabolic disorders and tendinopathies: Systematic review and meta-analysis.Journal of experimental orthopaedics · 2025Review
- Regulating inflammation microenvironment and tenogenic differentiation as sequential therapy promotes tendon healing in diabetic rats.Journal of orthopaedic translation · 2025Article
- How Does Tendon Region, Donor, and the Presence of Disease Affect Protein Composition of the Achilles Tendon?Clinical orthopaedics and related research · 2025Article
- Metabolic Risk Factors Relate to Worse Tendon Health in Individuals With Achilles Tendinopathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Exploring the Intersection of Diabetes and Musculoskeletal Health : Diabetes and Musculoskeletal Health.Galen medical journal · 2025Review
- Outcomes of Rotator Cuff Repair: Open vs. Arthroscopic Approaches in Patients with Diabetes or Hyperlipidemia.Journal of orthopaedics and sports medicine · 2025Article
- Investigating the mechanism of supraspinatus tendinopathy induced by type 2 diabetes mellitus in rats using untargeted metabolomics analysis.BMC musculoskeletal disorders · 2024Article
- Predictive ability of Achilles tendon elastography for frailty in older adults.European geriatric medicine · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus (DM) is associated with musculoskeletal complications-including tendon dysfunction and injury. Patients with DM show altered foot and ankle mechanics that have been attributed to tendon dysfunction as well as impaired recovery post-tendon injury. Despite the problem of DM-related tendon complications, treatment guidelines specific to this population of individuals are lacking. DM impairs tendon structure, function, and healing capacity in tendons throughout the body, but the Achilles tendon is of particular concern and most studied in the diabetic foot. At macroscopic levels, asymptomatic, diabetic Achilles tendons may show morphological abnormalities such as thickening, collagen disorganization, and/or calcific changes at the tendon enthesis. At smaller length scales, DM affects collagen sliding and discrete plasticity due to glycation of collagen. However, how these alterations translate to mechanical deficits observed at larger length scales is an area of continued investigation. In addition to dysfunction of the extracellular matrix, tendon cells such as tenocytes and tendon stem/progenitor cells show significant abnormalities in proliferation, apoptosis, and remodeling capacity in the presence of hyperglycemia and advanced glycation end-products, thus contributing to the disruption of tendon homeostasis and healing. Improving our understanding of the effects of DM on tendons-from molecular pathways to patients-will progress toward targeted therapies in this group at high risk of foot and ankle morbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.