ArticleJournal of diabetes science and technology2024
HbA1c Variability as an Independent Risk Factor for Microvascular Complications in Type 1 Diabetes.
Article in Journal of diabetes science and technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Chinese herbal compounds on ocular fundus signs and vision in conventional treated-persons with non-proliferative diabetic retinopathy: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Association of Variability of Monthly Continuous Glucose Monitoring-Derived Metrics With Diabetic Kidney Disease in Type 1 Diabetes.Diabetes, obesity & metabolism · 2026Article
- HbA1c as a Continuous Marker of Microvascular Vulnerability: Development of a Non-Linear Risk Framework in a Real-World Cohort.Metabolites · 2026Article
- Determinants of HbA1c Variability Across Clinical Subgroups: When the Same Value Does Not Reflect the Same Biological Risk.Medicina (Kaunas, Lithuania) · 2026Observational
- Clinical value of dyslipidemia and glycemic variability for progression to dementia in type 2 diabetes mellitus-associated mild cognitive impairment.Neurogenetics · 2025Article
- Variability in HbA1c and the risk of major clinical outcomes in type 2 diabetes with chronic kidney disease: Post hoc analysis from the CREDENCE trial.Diabetes, obesity & metabolism · 2025Article
- The Effects of Exercise Training on Body Composition and Cardiometabolic Risk Factors in Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2025Review
- Predictors of response to anti-VEGF combined with laser therapy in severe non-proliferative diabetic retinopathy: development and validation of a nomogram model from retrospective data.Frontiers in endocrinology · 2025Article
- The effect of HbA1C variability on the development and progression of diabetic nephropathy.Frontiers in clinical diabetes and healthcare · 2025Article
- HbADiabetologia · 2024Article
- Current landscape and comprehensive management of glycemic variability in diabetic retinopathy.Journal of translational medicine · 2024Review
- The Role of Natural Products in Diabetic Retinopathy.Biomedicines · 2024Review
Corrections and comments
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are few studies on the role of long-term glycemic variability in complications of type 1 diabetes (T1D). This study was aimed to investigate the associations of HbA1c variability represented by the coefficient of variation of HbA1c with incident microvascular complications in T1D by analyzing the data set from the DCCT/EDIC study.
methodsPatients (n = 1240) were divided into four groups by HbA1c variability quartiles. Incident microvascular complications were assessed for a duration of an average of 20.5 years. Multivariable models were performed to examine the associations between HbA1c variability and incident microvascular complications.
resultsAll incident microvascular complications were higher in the fourth quartile of the HbA1c variability group. After adjusting for clinical risk factors, HbA1c variability was positively associated with a higher risk of all diabetic microvascular complications (
conclusionsOur results showed a significant independent association between HbA1c variability and the risk of microvascular complications in T1D. HbA1c variability might be a supplemental risk stratification tool to mean HbA1c for microvascular complications in T1D.
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