Evidence map›Paper›PMID 35652638›Full record

ArticleMicrobiology spectrum2022

Restriction Checkpoint Controls Bradyzoite Development in Toxoplasma gondii.

Anatoli V Naumov, Chengqi Wang, Dale Chaput, Li-Min Ting, Carmelo A Alvarez, Thomas Keller, Ahmed Ramadan, Michael W White, Kami Kim, Elena S Suvorova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Anatoli V NaumovDepartment of Internal Medicine, Division of Infectious Diseases and International Medicine, Morsani College of Medicine, University of South Floridagrid.170693.a, Tampa, Florida, USA.
Chengqi WangCenter for Global Health and Infectious Diseases Research and USF Genomics Program, College of Public Health, University of South Floridagrid.170693.a, Tampa, Florida, USA.
Dale ChaputProteomics Core, College of Arts and Sciences, University of South Floridagrid.170693.a, Tampa, Florida, USA.
Li-Min TingDepartment of Internal Medicine, Division of Infectious Diseases and International Medicine, Morsani College of Medicine, University of South Floridagrid.170693.a, Tampa, Florida, USA.
Carmelo A AlvarezDepartment of Internal Medicine, Division of Infectious Diseases and International Medicine, Morsani College of Medicine, University of South Floridagrid.170693.a, Tampa, Florida, USA.
Thomas KellerDepartment of Internal Medicine, Division of Infectious Diseases and International Medicine, Morsani College of Medicine, University of South Floridagrid.170693.a, Tampa, Florida, USA.
Ahmed RamadanDepartment of Molecular Medicine, Morsani College of Medicine, University of South Floridagrid.170693.a, Tampa, Florida, USA.ORCID 0000-0003-0718-0852
Michael W WhiteDepartment of Internal Medicine, Division of Infectious Diseases and International Medicine, Morsani College of Medicine, University of South Floridagrid.170693.a, Tampa, Florida, USA.
Kami KimDepartment of Internal Medicine, Division of Infectious Diseases and International Medicine, Morsani College of Medicine, University of South Floridagrid.170693.a, Tampa, Florida, USA.
Elena S SuvorovaDepartment of Internal Medicine, Division of Infectious Diseases and International Medicine, Morsani College of Medicine, University of South Floridagrid.170693.a, Tampa, Florida, USA.ORCID 0000-0003-4482-8144
University of South Florida · US

Funding

Developmental switches regulating tissue cyst formationR01AI124682 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI WHITE, MICHAEL W · 2017 to 2021
$2.8M
Studies of DNA Licensing in Apicomplexa ParasitesR01AI122760 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI WHITE, MICHAEL W · 2016 to 2020
$2.6M
Centrosome control of Toxoplasma growthR01AI109843 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI WHITE, MICHAEL W · 2014 to 2018
$2.4M
Cyclin-mediated control of Toxoplasma developmentR01AI141467 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUVOROVA, ELENA · 2020 to 2024
$1.9M
Toxoplasma gondii cAMP-dependent kinase PKAc3 regulation of bradyzoite formationR21AI148374 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI KIM, KAMI · 2019 to 2020
$411k
New reporter system for spatiotemporal visualization of Toxoplasma gondii growth and developmentR03AI155834 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUVOROVA, ELENA · 2021 to 2022
$150k
NIAID NIH HHS R01 AI109843NIAID NIH HHS R01 AI122760NIAID NIH HHS R01 AI124682NIAID NIH HHS R01 AI141467NIAID NIH HHS R03 AI155834NIAID NIH HHS R21 AI148374
6 · The paper itself

Abstract

Human toxoplasmosis is a life-threatening disease caused by the apicomplexan parasite Toxoplasma gondii. Rapid replication of the tachyzoite is associated with symptomatic disease, while suppressed division of the bradyzoite is responsible for chronic disease. Here, we identified the T. gondii cell cycle mechanism, the G

Indexed as

ToxoplasmaToxoplasmosisAnimalsCell CycleCell DifferentiationCyclinsHumansRatsCyclinsapicomplexanbradyzoitecyclincyclin-dependent kinasedevelopmentToxoplasma gondii

Identifiers

PMID35652638
PMCPMC9241953
OpenAlexW4281701270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.