Evidence map›Paper›PMID 35652592›Full record

ArticlemBio2022

PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling.

Mikhail I Dobrikov, Elena Y Dobrikova, Zachary P McKay, Jonathan P Kastan, Michael C Brown, Matthias Gromeier

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Viral Microglia Reprogramming Clears Oligomeric Neurotoxic Debris.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Polio virotherapy provokes MDA5 signaling and CD4Microbiology and molecular biology reviews : MMBR · 2025
    Review
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mikhail I DobrikovDepartment of Neurosurgery, Duke Universitygrid.26009.3d Medical School, Durham, North Carolina, USA.
Elena Y DobrikovaDepartment of Neurosurgery, Duke Universitygrid.26009.3d Medical School, Durham, North Carolina, USA.
Zachary P McKayDepartment of Neurosurgery, Duke Universitygrid.26009.3d Medical School, Durham, North Carolina, USA.
Jonathan P KastanDepartment of Neurosurgery, Duke Universitygrid.26009.3d Medical School, Durham, North Carolina, USA.ORCID 0000-0001-6454-825X
Michael C BrownDepartment of Neurosurgery, Duke Universitygrid.26009.3d Medical School, Durham, North Carolina, USA.
Matthias GromeierDepartment of Neurosurgery, Duke Universitygrid.26009.3d Medical School, Durham, North Carolina, USA.ORCID 0000-0003-4538-0302
Duke University · US

Funding

Innate Antiviral Signals for Cancer ImmunotherapyR01NS108773 · NINDS · DUKE UNIVERSITY · PI Matthias Gromeier, Smita K. Nair · 2018 to 2026
$3.3M
Genetics and Genomics Training GrantT32GM136627 · NIGMS · DUKE UNIVERSITY · PI ALLISON E ASHLEY-KOCH · 2020 to 2026
$3.1M
Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass SpectrometerS10OD024999 · OD · DUKE UNIVERSITY · PI MOSELEY, MARTIN ARTHUR · 2018 to 2018
$600k
Cancer Immunotherapy Through Intratumoral Activation of Recall ResponsesF32CA224593 · NCI · DUKE UNIVERSITY · PI BROWN, MICHAEL CLAVON · 2018 to 2020
$187k
Reviving cancer immune surveillance with CD4 T cell helpK99CA263021 · NCI · DUKE UNIVERSITY · PI BROWN, MICHAEL CLAVON · 2021 to 2021
$105k
NCI NIH HHS F32 CA224593NCI NIH HHS K99 CA263021NIGMS NIH HHS T32 GM136627NINDS NIH HHS R01 NS108773
6 · The paper itself

Abstract

For RNA virus families except

Indexed as

EnterovirusPoliovirusRNA VirusesAntiviral AgentsImmunity, InnateInternal Ribosome Entry SitesReceptors, Pattern RecognitionRNA, Double-StrandedRNA, ViralAntiviral AgentsInternal Ribosome Entry SitesReceptors, Pattern RecognitionRNA, Double-StrandedRNA, Viraldendritic celleIF4GinterferonIRESMDA5PKRpoliovirusTBK1translation

Identifiers

PMID35652592
PMCPMC9239082
OpenAlexW4281704780

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.